Mitochondria: Much ado about nothing? How dangerous is reactive oxygen species production?☆
| العنوان: | Mitochondria: Much ado about nothing? How dangerous is reactive oxygen species production?☆ |
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| المؤلفون: | Eliška Holzerová, Holger Prokisch |
| المصدر: | The International Journal of Biochemistry & Cell Biology |
| بيانات النشر: | Elsevier, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | OXPHOS, oxidative phophorylation, Cellular differentiation, NADH DH, external NADH dehydrogenase, Mitochondrion, medicine.disease_cause, Biochemistry, Oxidative Phosphorylation, 0302 clinical medicine, DHODH, dihydroorotate dehydrogenase, NOS, nitric oxide synthase, I, complex I, chemistry.chemical_classification, 0303 health sciences, cyt, cytochrome, GPx, glutathione peroxidase, II, complex II, Cell Differentiation, 3. Good health, GSH GSSG, glutathione, Mitochondria, ROS signalization, GLRX, glutaredoxin, α-KGDH, α-ketoglutarate dehydrogenase, mGPDH, mitochondrial glycerophosphate dehydrogenase, MAO, monoamine oxidase, Cell signaling, TXNRD2, thioredoxin reductase, ROS scavenging, III, complex III, Oxidative phosphorylation, Biology, 03 medical and health sciences, ROS, reactive oxygen species, TXN2, thioredoxin 2, medicine, AO, alternative oxidase, Humans, 030304 developmental biology, TXN2, Reactive oxygen species, PRXIII, peroxiredoxin III, Cell Biology, ETF, electron transfer flavoprotein, PDH, pyruvate dehydrogenase, Oxidative Stress, chemistry, Organelles in Focus, IV, complex IV, Genome, Mitochondrial, Mutation, GSR, glutathione reductase, Energy Metabolism, Reactive Oxygen Species, 030217 neurology & neurosurgery, Homeostasis, Oxidative stress |
| الوصف: | For more than 50 years, reactive oxygen species have been considered as harmful agents, which can attack proteins, lipids or nucleic acids. In order to deal with reactive oxygen species, there is a sophisticated system developed in mitochondria to prevent possible damage. Indeed, increased reactive oxygen species levels contribute to pathomechanisms in several human diseases, either by its impaired defense system or increased production of reactive oxygen species. However, in the last two decades, the importance of reactive oxygen species in many cellular signaling pathways has been unraveled. Homeostatic levels were shown to be necessary for correct differentiation during embryonic expansion of stem cells. Although the mechanism is still not fully understood, we cannot only regard reactive oxygen species as a toxic by-product of mitochondrial respiration anymore.This article is part of a Directed Issue entitled: Energy Metabolism Disorders and Therapies. |
| اللغة: | English |
| تدمد: | 1878-5875 1357-2725 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e59d254c8ea7c7366cab51c3ced84c1 http://europepmc.org/articles/PMC4444525 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3e59d254c8ea7c7366cab51c3ced84c1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18785875 13572725 |
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