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Sex differences in body composition in people with prediabetes and type 2 diabetes as compared with people with normal glucose metabolism: the Maastricht Study

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العنوان: Sex differences in body composition in people with prediabetes and type 2 diabetes as compared with people with normal glucose metabolism: the Maastricht Study
المؤلفون: Rianneke de Ritter, Simone J. S. Sep, Marleen M. J. van Greevenbroek, Yvo H. A. M. Kusters, Rimke C. Vos, Michiel L. Bots, M. Eline Kooi, Pieter C. Dagnelie, Simone J. P. M. Eussen, Miranda T. Schram, Annemarie Koster, Martijn C. G. Brouwers, Niels M. R. van der Sangen, Sanne A. E. Peters, Carla J. H. van der Kallen, Coen D. A. Stehouwer
المساهمون: Interne Geneeskunde, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), Beeldvorming, MUMC+: DA BV Klinisch Fysicus (9), RS: Carim - B06 Imaging, Maastricht Studie, RS: CAPHRI - R5 - Optimising Patient Care, Epidemiologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: HVC Pieken Maastricht Studie (9), RS: CAPHRI - R4 - Health Inequities and Societal Participation, Sociale Geneeskunde, MUMC+: MA Endocrinologie (9), MUMC+: MA Interne Geneeskunde (3)
المصدر: Diabetologia, 66(5), 861-872. Springer, Cham
سنة النشر: 2023
مصطلحات موضوعية: RISK, INSULIN-RESISTANCE, DEXA, HIP, Fat mass, Endocrinology, Diabetes and Metabolism, Lean mass, WOMEN, Type 2 diabetes, MEN, Body composition, MASS INDEX, CIRCUMFERENCE, FAT, OBESITY, Sex differences, Internal Medicine, Liver fat, Prediabetes, MRI, ASSOCIATIONS
الوصف: Aims/hypothesis Obesity is a major risk factor for type 2 diabetes. However, body composition differs between women and men. In this study we investigate the association between diabetes status and body composition and whether this association is moderated by sex. Methods In a population-based cohort study (n=7639; age 40–75 years, 50% women, 25% type 2 diabetes), we estimated the sex-specific associations, and differences therein, of prediabetes (i.e. impaired fasting glucose and/or impaired glucose tolerance) and type 2 diabetes (reference: normal glucose metabolism [NGM]) with dual-energy x-ray absorptiometry (DEXA)- and MRI-derived measures of body composition and with hip circumference. Sex differences were analysed using adjusted regression models with interaction terms of sex-by-diabetes status. Results Compared with their NGM counterparts, both women and men with prediabetes and type 2 diabetes had more fat and lean mass and a greater hip circumference. The differences in subcutaneous adipose tissue, hip circumference and total and peripheral lean mass between type 2 diabetes and NGM were greater in women than men (women minus men [W–M] mean difference [95% CI]: 15.0 cm2 [1.5, 28.5], 3.2 cm [2.2, 4.1], 690 g [8, 1372] and 443 g [142, 744], respectively). The difference in visceral adipose tissue between type 2 diabetes and NGM was greater in men than women (W–M mean difference [95% CI]: −14.8 cm2 [−26.4, −3.1]). There was no sex difference in the percentage of liver fat between type 2 diabetes and NGM. The differences in measures of body composition between prediabetes and NGM were generally in the same direction, but were not significantly different between women and men. Conclusions/interpretation This study indicates that there are sex differences in body composition associated with type 2 diabetes. The pathophysiological significance of these sex-associated differences requires further study. Graphical abstract
اللغة: English
تدمد: 0012-186X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7eb1affd89fdc5997f06e19774e932
https://doi.org/10.1007/s00125-023-05880-0
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....3e7eb1affd89fdc5997f06e19774e932
قاعدة البيانات: OpenAIRE
الوصف
تدمد:0012186X