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A comparative study of the photophysical and phototoxic properties of octakis(decyloxy)phthalocyaninato zinc(II), incorporated in a hydrophilic polymer, in liposomes and in non-ionic micelles

التفاصيل البيبلوغرافية
العنوان: A comparative study of the photophysical and phototoxic properties of octakis(decyloxy)phthalocyaninato zinc(II), incorporated in a hydrophilic polymer, in liposomes and in non-ionic micelles
المؤلفون: Daniel A. Fernández, Lelia E. Dicelio, Analía Bonansea, Cristian A. Strassert, Myriam E. Rodriguez, Josefina Awruch, Marisa Monetti, Flavia Morán, Viviana Rivarola
المصدر: Photochemicalphotobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2(10)
سنة النشر: 2003
مصطلحات موضوعية: Cell Survival, Photochemistry, Polymers, medicine.medical_treatment, chemistry.chemical_element, Photodynamic therapy, Apoptosis, Zinc, Micelle, Cell Line, Necrosis, medicine, Organometallic Compounds, Humans, Physical and Theoretical Chemistry, Micelles, chemistry.chemical_classification, Liposome, Photosensitizing Agents, Chemistry, Polymer, Fluorescence, Photobiology, Photochemotherapy, Lipophilicity, Liposomes, Phototoxicity, Dimyristoylphosphatidylcholine
الوصف: Factors such as charge, aggregation and lipophilicity influence photosensitiser localisation. The lipophilic octasubstituted sensitiser 2,3,9,10,16,17,23,24-octakis(decyloxy)phthalocyaninato zinc(II) was incorporated into liposomes of dimyristoyl-L-alpha-phosphatidylcholine (DMPC), non-ionic micelles of Tween 80 and the hydrosoluble polymer Solutol HS 15 in order to investigate how these different environments affect the photophysical properties and phototoxicity of the photosensitiser. Fluorescence quantum yields and singlet molecular oxygen generation are enhanced in the presence of Solutol HS 15. Phototoxicities were calculated by employing a concentration of 10(-7) M of the dye against the Hep-2 cell line, which showed a viability of 53 and 30% in DMPC and Solutol HS 15, respectively. After 24 h of photodynamic therapy with 15 min irradiation, apoptotic and necrotic cells were observed.
تدمد: 1474-905X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e881556de9d7bb61f31c82a5b93d5be
https://pubmed.ncbi.nlm.nih.gov/14606753
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....3e881556de9d7bb61f31c82a5b93d5be
قاعدة البيانات: OpenAIRE
الوصف
تدمد:1474905X