التفاصيل البيبلوغرافية
العنوان:
Effect of accompanying antiretroviral drugs on virological response to pegylated interferon and ribavirin in patients co-infected with HIV and hepatitis C virus
المؤلفون:
M. A. Sanfrutos , S. Carretero , José Mallolas , Mercè Pérez , Esther Aznar , Elena Urbaneja Rodríguez , Miguel Ángel Von-Wichmann , José L. Casado , L. Ortiz , Leganés: R. Torres , Manel Crespo , J. F. Pascual , M. J. Galindo , Julio De Miguel , Sari Arponen , Sonia Moreno , M. Sánchez Conde , Pere Domingo , S. Schroeder , J. Berenguer , José López-Aldeguer , Rafael M. Rubio , B. Moyano , Francisco Xavier Zamora , Herminia Esteban , Josep M. Guardiola , Elena Barquilla , María Jesús Téllez , M. Blanes , I. Gutiérrez , F. Tejerina , A. Jou , Juan Berenguer , Esteban Ribera , J. de Miguel , Alberto Arranz , Emilia Condes , A. Moreno , J. Lacruz , E. Barquilla , Federico Pulido , Juan González-García , Miguel Cervero , José M. Peña , José Sanz , Carlos Quereda , J. M. Bellón , Juan J. Jusdado , Manuel Crespo , José Antonio Iribarren , V. Rodríguez , Pilar Miralles , Marisa Montes , Josep Mallolas , B. Mahillo , J. López-Aldeguer , Enrique Ortega , I. Bernardino , M. Ramírez , M. Cotarelo , J Gonzalez-Garcia , M.J. Pérez-Elías , E. Van den Eynde , Teresa Aldámiz-Echevarría , A. Ferrer , Esperanza Casas , J. Alvarez-Pellicer , Miró Jm , Belén Padilla , Miguel A. Von Wichmann , Iria Santos , Miguel Salavert , Francisco Arnalich , J. M. Guardiola , Jose R. Arribas , F Rodríguez-Arrondo , Sandra Cuellar , Jorge Vergas , Carlos Barros , Carmen Quereda , María José Galindo , Gabriel Gaspar , Cristina Tural , José María Bellón , Julio Álvarez-Pellicer , Gloria Perez , P. Miralles , Gatell Jm , J. C. López , P. Callau , Asunción Hernando , M. J. Téllez , Fernando Dronda , Jaime Cosín , M. J. Bustinduy , Marta Montero
المصدر:
The Journal of antimicrobial chemotherapy . 66(12)
سنة النشر:
2011
مصطلحات موضوعية:
Microbiology (medical) , Oncology , Adult , Male , medicine.medical_specialty , Sida , Hepatitis C virus , HIV Infections , Emtricitabine , medicine.disease_cause , Antiviral Agents , chemistry.chemical_compound , Zidovudine , Pegylated interferon , Internal medicine , Antiretroviral Therapy, Highly Active , Ribavirin , Medicine , Humans , Pharmacology (medical) , Drug Interactions , Treatment Failure , Retrospective Studies , Pharmacology , business.industry , virus diseases , Lamivudine , Hepatitis C , Hepatitis C, Chronic , Viral Load , medicine.disease , Virology , digestive system diseases , Infectious Diseases , chemistry , Spain , Female , Interferons , business , Viral load , medicine.drug
الوصف:
Objectives: The effects of antiretroviral drugs on the response to pegylated interferon plus ribavirin remain uncertain. We evaluated whether antiretroviral drugs affected the response to pegylated interferon plus ribavirin in patients co-infected with HIV and hepatitis C virus (HCV). Methods: We conducted a retrospective analysis of two cohorts of HIV/HCV-co-infected patients treated with pegylated interferon plus ribavirin between 2001 and 2007 in Spain. The outcome measure was sustained virological response (SVR). Logistic regression models were used to test possible associations between non-response and pre-treatment characteristics, including accompanying antiretroviral drugs. Results: The study sample comprised 1701 patients: 63% were infected with HCV genotype (G) 1 or 4 and 88% were taking highly active antiretroviral therapy (HAART). Factors independently associated with increased odds of SVR were G2 or 3, HVC RNA,500000 IU/mL and CDC clinical category A or B. When we adjusted for these prognostic factors and dose of ribavirin/kg, the adjusted odds ratio (AOR) of SVR for patients without HAART was 1.31 [95% confidence interval (CI) 0.91-1.88; P=0.144]. Taking the backbone of tenofovir and lamivudine/emtricitabine as a reference, we found that, with the exception of regimens including zidovudine, the effect of other nucleoside reverse transcriptase inhibitor backbones had little effect on SVR. The AOR of SVR for zidovudine and lamivudine was 0.65 (95% CI 0.46-0.93, P=0.017). We carried out several sensitivity analyses, the results of which were consistent with the findings of the primary analysis. Conclusions: Our results suggest that, with the exception of regimens including zidovudine, accompanying antiretroviral drugs have little effect on the virological response to pegylated interferon plus ribavirin in HIV/HCV-co-infected patients. © The Author 2011. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
تدمد:
1460-2091
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eec71ba71500caf3ca962d18d58fa42 https://pubmed.ncbi.nlm.nih.gov/21965432
حقوق:
OPEN
رقم الأكسشن:
edsair.doi.dedup.....3eec71ba71500caf3ca962d18d58fa42
قاعدة البيانات:
OpenAIRE
