Urothelial Cell Intracytoplasmic Inclusions After Treatment of Promyelocytic Leukemia With Arsenic Trioxide
| العنوان: | Urothelial Cell Intracytoplasmic Inclusions After Treatment of Promyelocytic Leukemia With Arsenic Trioxide |
|---|---|
| المؤلفون: | Subodh M. Lele, Samuel M. Cohen, Lori J Maness-Harris, Rose Hoyt, Lora L. Arnold, Whitney Wedel, Puttappa R. Dodmane, David Muirhead |
| المصدر: | Toxicological Sciences. 134:271-275 |
| بيانات النشر: | Oxford University Press (OUP), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, Acute promyelocytic leukemia, Pathology, medicine.medical_specialty, Urothelial Cell, Cytoplasmic inclusion, chemistry.chemical_element, Toxicology, Arsenicals, chemistry.chemical_compound, Arsenic Trioxide, Leukemia, Promyelocytic, Acute, Microscopy, Electron, Transmission, Tretinoin, medicine, Humans, Arsenic trioxide, Arsenic, Aged, Urine cytology, Inclusion Bodies, medicine.diagnostic_test, Chemistry, Oxides, Middle Aged, medicine.disease, Microscopy, Fluorescence, Case-Control Studies, Micronucleus test, Female, Urothelium, medicine.drug |
| الوصف: | Intramitochondrial inclusions containing arsenite that occur within urothelial cells have been previously described in mice exposed to high concentrations of arsenic but not in rats. In epidemiology studies, similar urothelial cell inclusions have also been observed in the urine of humans exposed to high concentrations of arsenic in the drinking water; however, these inclusions were mistakenly identified as micronuclei. To further examine the urothelial cell inclusions that occur in inorganic arsenic-exposed humans, we evaluated two patients with a history of acute promyelocytic leukemia treated for disease relapse with a combination of all-trans retinoic acid and arsenic trioxide. Posttreatment examination of the patients' urine cytology specimens by light and electron microscopy demonstrated cytoplasmic inclusions in exfoliated superficial urothelial cells similar to those seen in mice. The inclusions were present in decreasing quantities at 3 and 7 months after completion of treatment. No comparable inclusions were detected in exfoliated urothelial cells in urine from six individuals not treated with arsenic trioxide. Based on the results of the examination by light and electron microscopy, we have determined that urothelial cell inclusions in the urine of humans previously identified as micronuclei are instead intracytoplasmic inclusions similar to those found in arsenic-treated mice. |
| تدمد: | 1096-0929 1096-6080 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9bfc910ecc2c0512d6d08a2433770a https://doi.org/10.1093/toxsci/kft120 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3f9bfc910ecc2c0512d6d08a2433770a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10960929 10966080 |
|---|