The leading role of pathology in assessing the somatic molecular alterations of cancer: Position Paper of the European Society of Pathology
| العنوان: | The leading role of pathology in assessing the somatic molecular alterations of cancer: Position Paper of the European Society of Pathology |
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| المؤلفون: | Matias-Guiu, Xavier, Stanta, Giorgio, Carneiro, Fátima, Ryska, Ales, Hoefler, Gerald, Moch, Holger, European Society of Pathology (ESP) |
| المساهمون: | University of Zurich, Matias-Guiu, Xavier |
| المصدر: | Virchows Archiv Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de la UB Universidad de Barcelona Repositorio Abierto de la UdL Universitad de Lleida |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Pathology, medicine.medical_specialty, Pre-analytical issues, Somatic cell, Medical laboratory, 610 Medicine & health, Context (language use), Pathology and Forensic Medicine, 1307 Cell Biology, 03 medical and health sciences, 0302 clinical medicine, 10049 Institute of Pathology and Molecular Pathology, Neoplasms, 1312 Molecular Biology, medicine, Biomarkers, Tumor, Molecular diagnostics, Humans, Patologia molecular, Pathology, Molecular, Precision Medicine, Càncer, Molecular Biology, Cancer, Molecular pathology, business.industry, Cell Biology, General Medicine, medicine.disease, Molecular analysis, 2734 Pathology and Forensic Medicine, Review and Perspectives, Europe, Pathologists, 030104 developmental biology, 030220 oncology & carcinogenesis, Scientific domain, Commentary, Position paper, business, Integrative pathology |
| الوصف: | Molecular pathology is an essential part of pathology complementing conventional morphological tools to obtain a correct integrated diagnosis with appropriate assessment of prognosis and prediction of response to therapy, particularly in cancer. There is a concern about the situation of molecular pathology in some areas of Europe, namely, regarding the central role of pathologists in assessing somatic genomic alterations in cancer. In some countries, there are attempts that other laboratory medicine specialists perform the molecular analysis of somatic alterations in cancer, particularly now when next generation sequencing (NGS) is incorporated into clinical practice. In this scenario, pathologists may play just the role of "tissue providers," and other specialists may take the lead in molecular analysis. Geneticists and laboratory medicine specialists have all background and skills to perform genetic analysis of germline alterations in hereditary disorders, including familial forms of cancers. However, interpretation of somatic alterations of cancer belongs to the specific scientific domain of pathology. Pathologists are necessary to guarantee the quality of the results, for several reasons: (1) The identified molecular alterations should be interpreted in the appropriate morphologic context, since most of them are context-specific; (2) pre-analytical issues must be taken into consideration; (3) it is crucial to check the proportion of tumor cells in the sample subjected to analysis and presence of inflammatory infiltrate and necrosis should be monitored; and 4) the role of pathologists is crucial to select the most appropriate methods and to control the turnaround time in which the molecular results are delivered in the context of an integrated diagnosis. Obviously, there is the possibility of having core facilities for NGS in a hospital to perform the sequence analysis that are open to other specialties (microbiologists, geneticists), but also in this scenario, pathologists should have the lead in assessing somatic alterations of cancer. In this article, we emphasize the importance of interpreting somatic molecular alterations of the tumors in the context of morphology. In this Position Paper of the European Society of Pathology, we strongly support a central role of pathology departments in the process of analysis and interpretation of somatic molecular alterations in cancer. The proposal for this position paper was approved by the Publication Task Force of the European Society of Pathology (ESP), and this approval was subsequently verified by the Council of ESP. We thank Mar Varela, Dolors Cuevas, Ana Velasco and Jordi Temprana for help in writing the manuscript. |
| وصف الملف: | application/pdf; Matias-Guiu2020_Article_TheLeadingRoleOfPathologyInAss.pdf - application/pdf |
| تدمد: | 1432-2307 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb0ee2906f2ce00b585654edbe6f440 https://pubmed.ncbi.nlm.nih.gov/32761392 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3fb0ee2906f2ce00b585654edbe6f440 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14322307 |
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