A Clinicopathological Study of Young-onset Hepatocellular Carcinoma
| العنوان: | A Clinicopathological Study of Young-onset Hepatocellular Carcinoma |
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| المؤلفون: | Regina Cheuk-Lam Lo, Kristy Kwan-Shuen Chan, Kwan-Yung Au |
| المصدر: | Anticancer Research. 41:2933-2944 |
| بيانات النشر: | Anticancer Research USA Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, medicine.medical_specialty, Carcinoma, Hepatocellular, Adolescent, Young onset, medicine.disease_cause, Gastroenterology, Young Adult, Glypicans, Internal medicine, medicine, Hotspot mutation, Humans, Age of Onset, Child, TP53 Gene Mutation, beta Catenin, Retrospective Studies, Keratin-19, Mutation, business.industry, Liver Neoplasms, General Medicine, Genes, p53, medicine.disease, Oncology, Hepatocellular carcinoma, Cohort, Immunohistochemistry, Female, Liver cancer, business |
| الوصف: | Background/aim The aim of this study was to describe the clinicopathological features of hepatocellular carcinoma (HCC) diagnosed at 40 years of age or below. Materials and methods Expression of CK19, Glypican-3 and β-catenin was assessed in clinical samples by immunohistochemistry (IHC). IHC expression was correlated with clinicopathological parameters. Hotspot mutations in TP53 gene were analyzed by sequencing. Results Thirty-six cases were included with a male to female ratio of 3:1. Eighty percent of cases were associated with chronic hepatitis B infection. CK19 and GPC3 were expressed in 61% and 56% of cases, respectively. Only one case demonstrated β-catenin over-expression. TP53 hotspot mutation was identified in 4 cases. Number of tumor nodules, vascular invasion, and preoperative serum AFP level were associated with prognosis. Conclusion A higher CK19 expression rate was observed in our young-onset HCC cohort, whereas β-catenin pathway activation and TP53 gene mutation events were less frequent. Conventional clinicopathological parameters remain predictors of survival. |
| تدمد: | 1791-7530 0250-7005 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc647341fdb9a2db411647475cc4e13 https://doi.org/10.21873/anticanres.15075 |
| رقم الأكسشن: | edsair.doi.dedup.....3fc647341fdb9a2db411647475cc4e13 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17917530 02507005 |
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