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What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons

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العنوان: What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons
المؤلفون: Marco Weiergräber, Andrej Cichocki, Görsev Yener, John-Paul Taylor, William J. McGeown, Willem de Haan, Jaeseung Jeong, Zbigniew R. Struzik, Tracy L. Young-Pearse, Marco Onofrj, Wilhelmus Drinkenburg, Giovanni B. Frisoni, Claudio Del Percio, Alberto Fernández, Bahar Güntekin, Sanjeev Kumar, Kelly Kilborn, Harald Hampel, Ian G. McKeith, Heikki Tanila, Fernando H. Lopes da Silva, Fiona Randall, Bruno Dubois, Magnus Johannsson, Michael J. Rowan, John M Olichney, Davide V. Moretti, Kristinn Johnsen, Javier Escudero, Fernando Maestú, Claudio Babiloni, Katarzyna J. Blinowska, Roberta Lizio, Fabrizio Stocchi, Mihály Hajós, Stefan J. Teipel, Laura Bonanni, Emmanuel Ifeachor, Fiona E. N. LeBeau, Flavio Nobili, Jorge J. Palop
المصدر: Babiloni, C, Blinowska, K, Bonanni, L, Cichocki, A, De Haan, W, Del Percio, C, Dubois, B, Escudero, J, Fernández, A, Frisoni, G, Guntekin, B, Hajos, M, Hampel, H, Ifeachor, E, Kilborn, K, Kumar, S, Johnsen, K, Johannsson, M, Jeong, J, LeBeau, F, Lizio, R, Lopes da Silva, F, Maestú, F, McGeown, W J, McKeith, I, Moretti, D V, Nobili, F, Olichney, J, Onofrj, M, Palop, J J, Rowan, M, Stocchi, F, Struzik, Z M, Tanila, H, Teipel, S, Taylor, J P, Weiergräber, M, Yener, G, Young-Pearse, T, Drinkenburg, W H & Randall, F 2020, ' What electrophysiology tells us about Alzheimer's disease : a window into the synchronization and connectivity of brain neurons ', Neurobiology of Aging, vol. 85, pp. 58-73 . https://doi.org/10.1016/j.neurobiolaging.2019.09.008
Babiloni, C, Blinowska, K, Bonanni, L, Cichocki, A, De Haan, W, del Percio, C, Dubois, B, Escudero, J, Fernández, A, Frisoni, G B, Guntekin, B, Hajos, M, Hampel, H, Ifeachor, E, Kilborn, K, Kumar, S, Johnsen, K, Johannsson, M, Jeong, J, LeBeau, F, Lizio, R, Lopes da Silva, F, Maestú, F, McGeown, W J, McKeith, I G, Moretti, D V, Nobili, F, Olichney, J M, Onofrj, M, Palop, J J, Rowan, M, Stocchi, F, Struzik, Z, Tanila, H, Teipel, S, Taylor, J-P, Weiergräber, M, Yener, G, Young-Pearse, T, Drinkenburg, W H & Randall, F 2020, ' What Electrophysiology Tells Us About Alzheimer’s Disease: A Window into the Synchronization and Connectivity of Brain Neurons ', Neurobiology of Aging, vol. 85, pp. 58-73 . https://doi.org/10.1016/j.neurobiolaging.2019.09.008
Neurobiology of aging 85, 58-73 (2020). doi:10.1016/j.neurobiolaging.2019.09.008
بيانات النشر: Elsevier Inc., 2020.
سنة النشر: 2020
مصطلحات موضوعية: 0301 basic medicine, Aging, Electroencephalography and magnetoencephalography (EEG and MEG), Preclinical and clinical research, Alzheimer’s disease (AD), Electroencephalography and Magnetoencephalography (EEG and MEG), physiopathology [Brain], Electroencephalography, pathology [Alzheimer Disease], 0302 clinical medicine, pathology [Brain], Drug Discovery, Event-related potentials and magnetic fields, Alzheimer's disease (AD), Resting-state condition, The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART), Evoked Potentials, medicine.diagnostic_test, General Neuroscience, diagnosis [Alzheimer Disease], Brain, Magnetoencephalography, Electrophysiology, Tauopathy, Alzheimer's disease, Cortical Synchronization, Neuropathology, Event-Related Potentials and Magnetic Fields, physiopathology [Alzheimer Disease], 03 medical and health sciences, Slice preparation, Alzheimer Disease, medicine, Animals, Humans, ddc:610, methods [Electrophysiology], business.industry, Neurophysiology, medicine.disease, 030104 developmental biology, Resting State Condition, Neurology (clinical), Geriatrics and Gerontology, business, Neuroscience, 030217 neurology & neurosurgery, Developmental Biology
الوصف: Electrophysiology provides a real-time readout of neural functions and network capability in different brain states, on temporal (fractions of milliseconds) and spatial (micro, meso, and macro) scales unmet by other methodologies. However, current international guidelines do not endorse the use of electroencephalographic (EEG)/magnetoencephalographic (MEG) biomarkers in clinical trials performed in patients with Alzheimer's disease (AD), despite a surge in recent validated evidence. This position paper of the ISTAART Electrophysiology Professional Interest Area endorses consolidated and translational electrophysiological techniques applied to both experimental animal models of AD and patients, to probe the effects of AD neuropathology (i.e., brain amyloidosis, tauopathy, and neurodegeneration) on neurophysiological mechanisms underpinning neural excitation/inhibition and neurotransmission as well as brain network dynamics, synchronization, and functional connectivity, reflecting thalamocortical and corticocortical residual capacity. Converging evidence shows relationships between abnormalities in EEG/MEG markers and cognitive deficits in groups of AD patients at different disease stages. The supporting evidence for the application of electrophysiology in AD clinical research as well as drug discovery pathways warrants an international initiative to include the use of EEG/MEG biomarkers in the main multicentric projects planned in AD patients, to produce conclusive findings challenging the present regulatory requirements and guidelines for AD studies. (C) 2019 Elsevier Inc. All rights reserved.
وصف الملف: application/pdf
اللغة: English
تدمد: 0197-4580
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc9dbb6cb8577831ba5a95c1fc146e1
http://hdl.handle.net/11567/997169
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....3fc9dbb6cb8577831ba5a95c1fc146e1
قاعدة البيانات: OpenAIRE
الوصف
تدمد:01974580