أعرض في EDS

Disruption of superficial white matter in the emotion regulation network in bipolar disorder

التفاصيل البيبلوغرافية
العنوان: Disruption of superficial white matter in the emotion regulation network in bipolar disorder
المؤلفون: Shuming Zhong, Shufei Zhang, Ruiwang Huang, Yanbin Jia, Ying Wang, Guanmao Chen, Ping Chen, Xiaomei Luo, Shaojuan Qiu, Feng Deng, Huiqing Hu, Sunkai Lai, Li Huang, Lixiang Chen, Huiyuan Huang
المصدر: NeuroImage : Clinical
NeuroImage: Clinical, Vol 20, Iss, Pp 875-882 (2018)
سنة النشر: 2018
مصطلحات موضوعية: Male, Bipolar Disorder, MDSWM, MD, mean diffusivity, Tr, pars triangularis gyrus, Emotions, PoC, postcentral gyrus, BD, bipolar disorder, lcsh:RC346-429, 0302 clinical medicine, Neural Pathways, dlPFC, dorsolateral prefrontal cortex, HC, healthy controls, Prefrontal cortex, Cerebral Cortex, education.field_of_study, Op, pars opercularis gyrus, vlPFC, ventrolateral prefrontal cortex, 05 social sciences, Regular Article, FASWM, FA, fractional anisotropy, White Matter, Probabilistic tractography, RMF, rostral middle frontal gyrus, medicine.anatomical_structure, Diffusion tensor imaging, Neurology, lcsh:R858-859.7, Female, IP, inferior parietal gyrus, Tract-based spatial statistics (TBSS), Adult, Ventrolateral prefrontal cortex, Cognitive Neuroscience, RAC, rostral anterior cingulate gyrus, Population, Deep white matter (DWM), SF, superior frontal gyrus, Posterior parietal cortex, Cortico-cortical connection, lcsh:Computer applications to medicine. Medical informatics, 050105 experimental psychology, Self-Control, White matter, 03 medical and health sciences, Young Adult, CMF, caudal middle frontal gyrus, HAMD, Hamilton Depression Scale, YMRS, Young Mania Rating Scale, Fractional anisotropy, medicine, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, SM, supramarginal gyrus, WM, white matter, education, lcsh:Neurology. Diseases of the nervous system, ADSWM, AD, axonal diffusivity measured in the SWM, business.industry, mPFC, medial prefrontal cortex, Dorsolateral prefrontal cortex, Diffusion Magnetic Resonance Imaging, LOF, lateral orbitofrontal gyrus, RDSWM, RD, radial diffusivity, SP, superior parietal gyrus, PrC, precentral gyrus, Anisotropy, GM, gray matter, Neurology (clinical), business, Neuroscience, 030217 neurology & neurosurgery, Diffusion MRI
الوصف: Bipolar disorder (BD) is characterized by emotion dysregulation and involves changes in the gray matter (GM) and white matter (WM). Although previous diffusion tensor imaging (DTI) studies reported changes in the diffusion properties of the deep WM (DWM) in BD patients, the diffusion properties of the superficial WM (SWM) are rarely investigated. In this study, we tried to determine whether the diffusion parameters of the SWM were altered in BD patients compared to controls and whether the changes were associated with the disrupted emotion regulation of the BD patients. We collected DTI data from 37 BD patients and 42 gender- and age-matched healthy controls (HC). Using probabilistic tractography, we defined a population-based SWM mask based on all the subjects. After performing the tract-based spatial statistical (TBSS) analyses, we identified the SWM areas in which the BD patients differed from the controls. This study showed significantly reduced fractional anisotropy in the SWM (FASWM) in the BD patients compared to the HC in the bilateral dorsolateral prefrontal cortex (dlPFC), ventrolateral prefrontal cortex (vlPFC), medial prefrontal cortex (mPFC), and the left parietal cortex. Moreover, compared to the controls, the BD patients showed significantly increased mean diffusivity (MDSWM) and radial diffusivity (RDSWM) in the SWM in the right frontal cortex. This study presents altered cortico-cortical connections proximal to the regions related to the emotion dysregulation of BD patients, which indicated that the SWM may serve as the brain's structural basis underlying the disrupted emotion regulation of BD patients. The disrupted FASWM in the parietal cortex may indicate that the emotion dysregulation in BD patients is related to the cognitive control network.
Highlights • BD patients showed altered FASWM in the regions related to emotion dysregulation. • Disrupted SWM may be the brain's structural basis underlying emotion dysregulation in BD patients. • FASWM between the vlPFC and dlPFC was negatively correlated with disease exacerbations in BD patients. • Emotion dysregulation in BD patients may be related to a disrupted cognitive control network.
تدمد: 2213-1582
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdc53d8207770b093e71ee2c985cbe0
https://pubmed.ncbi.nlm.nih.gov/30286386
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....3fdc53d8207770b093e71ee2c985cbe0
قاعدة البيانات: OpenAIRE
الوصف
تدمد:22131582