Optimization of the safety and efficacy of interferon beta 1b and azathioprine combination therapy in multiple sclerosis
| العنوان: | Optimization of the safety and efficacy of interferon beta 1b and azathioprine combination therapy in multiple sclerosis |
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| المؤلفون: | J. L. Wilterdink, K Costello, C. N. Bash, Areen T Said, M. Pulicken, C. Cuffari, Jeffrey M. Rogg, P. Mills, Peter A. Calabresi |
| المصدر: | Multiple Sclerosis Journal. 11:169-174 |
| بيانات النشر: | SAGE Publications, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Male, Oncology, medicine.medical_specialty, Multiple Sclerosis, Combination therapy, medicine.medical_treatment, Pilot Projects, Azathioprine, Tioguanine, 03 medical and health sciences, 0302 clinical medicine, Adjuvants, Immunologic, Internal medicine, medicine, Humans, 030212 general & internal medicine, Leukopenia, business.industry, Multiple sclerosis, Interferon beta-1b, Immunosuppression, Interferon-beta, Middle Aged, medicine.disease, Surgery, Clinical trial, Treatment Outcome, Neurology, Drug Therapy, Combination, Female, Neurology (clinical), medicine.symptom, business, Immunosuppressive Agents, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | We conducted an open-label pilot clinical trial to evaluate the safety and efficacy of adding oral azathioprine to the treatment regimen of 15 multiple sclerosis patients breaking through monotherapy with interferon β-1b. There were no serious adverse events. Gastrointestinal side effects and leukopenia were the most common adverse events and limited dose escalation. There was a 65% reduction in the number of gadolinium-enhanced magnetic resonance imaging (MRI) lesions on combination therapy compared to the baseline values (P=0.003). A total WBC count less than 4800/mm3 was the best predictor of MRI response. |
| تدمد: | 1477-0970 1352-4585 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3febb0ba75afbb2c1b2648730d90e359 https://doi.org/10.1191/1352458505ms1141oa |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....3febb0ba75afbb2c1b2648730d90e359 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14770970 13524585 |
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