Exploring natural killer cell immunology as a therapeutic strategy in lung cancer
| العنوان: | Exploring natural killer cell immunology as a therapeutic strategy in lung cancer |
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| المؤلفون: | Sarah A. Best, Kate D. Sutherland, Jonas B. Hess |
| المصدر: | Transl Lung Cancer Res |
| بيانات النشر: | AME Publishing Company, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adoptive cell transfer, Innate immune system, business.industry, medicine.medical_treatment, Immunotherapy, medicine.disease, Natural killer cell, Immunosurveillance, Immune system, medicine.anatomical_structure, Oncology, Immunology, medicine, Cytotoxic T cell, Review Article on Lung Cancer and The Immune System, Lung cancer, business |
| الوصف: | Cytotoxic immune cells are key in the control of tumor development and progression. Natural killer (NK) cells are the cytotoxic arm of the innate immune system with the capability to kill tumor cells and surveil tumor cell dissemination. As such, the interest in harnessing NK cells in tumor control is increasing in many solid tumor types, including lung cancer. Here, we review the pre-clinical models used to unveil the role of NK cells in immunosurveillance of solid tumors and highlight measures to enhance NK cell activity. Importantly, the development of NK immunotherapy is rapidly evolving. Enhancing the NK cell response can be achieved using two broad modalities: enhancing endogenous NK cell activity, or performing adoptive transfer of pre-activated NK cells to patients. Numerous clinical trials are evaluating the efficacy of NK cell immunotherapy in isolation or in combination with standard treatments, with encouraging initial results. Pre-clinical studies and early phase clinical trials suggest that patients with solid tumors, including lung cancer, have the potential to benefit from recent developments in NK cell immunotherapy. |
| تدمد: | 2226-4477 2218-6751 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff21d34d59352b9ea8438b7887ed324 https://doi.org/10.21037/tlcr-20-765 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3ff21d34d59352b9ea8438b7887ed324 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22264477 22186751 |
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