Anatomical and single-cell transcriptional profiling of the murine habenular complex
| العنوان: | Anatomical and single-cell transcriptional profiling of the murine habenular complex |
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| المؤلفون: | Kee Wui Huang, Bernardo L. Sabatini, Gianna Radeljic, Michael L. Wallace, Daniel Hochbaum, Minsuk Hyun |
| المصدر: | eLife eLife, Vol 9 (2020) |
| بيانات النشر: | eLife Sciences Publications, Ltd, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | endocrine system, Mouse, QH301-705.5, Science, Cell, Biology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Mice, 0302 clinical medicine, Dopamine, medicine, Animals, Biology (General), GABAergic Neurons, 030304 developmental biology, 0303 health sciences, Brain Mapping, Habenula, General Immunology and Microbiology, General Neuroscience, Dopaminergic Neurons, Gene Expression Profiling, Dopaminergic, Ventral Tegmental Area, General Medicine, Retrograde tracing, serotonin, Ventral tegmental area, medicine.anatomical_structure, nervous system, Medicine, GABAergic, Serotonin, dopamine, Single-Cell Analysis, Transcriptome, Neuroscience, 030217 neurology & neurosurgery, hormones, hormone substitutes, and hormone antagonists, VTA, medicine.drug, Research Article |
| الوصف: | The lateral habenula (LHb) is an epithalamic brain structure critical for processing and adapting to negative action outcomes. However, despite the importance of LHb to behavior and the clear anatomical and molecular diversity of LHb neurons, the neuron types of the habenula remain unknown. Here, we use high-throughput single-cell transcriptional profiling, monosynaptic retrograde tracing, and multiplexed FISH to characterize the cells of the mouse habenula. We find five subtypes of neurons in the medial habenula (MHb) that are organized into anatomical subregions. In the LHb, we describe four neuronal subtypes and show that they differentially target dopaminergic and GABAergic cells in the ventral tegmental area (VTA). These data provide a valuable resource for future study of habenular function and dysfunction and demonstrate neuronal subtype specificity in the LHb-VTA circuit. |
| اللغة: | English |
| تدمد: | 2050-084X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405db08a8cf681d38d87d7c15a088e0d http://europepmc.org/articles/PMC7012610 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....405db08a8cf681d38d87d7c15a088e0d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2050084X |
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