Diagnostic value of urinary microprotein concentration for patients with negative urinary protein test results and positive urinary casts on microscopic examination
| العنوان: | Diagnostic value of urinary microprotein concentration for patients with negative urinary protein test results and positive urinary casts on microscopic examination |
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| المؤلفون: | Chun-Sheng Zheng, Ji-Lai Liu, Xue-Jun Qin, Rong-Yan Chen, Yangyu Li, Wen-Hua Wang |
| المصدر: | Journal of Clinical Laboratory Analysis |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), Urinary protein, medicine.medical_specialty, Urinary system, Clinical Biochemistry, cast, Physical examination, Urine, Urinalysis, Sensitivity and Specificity, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Alpha-Globulins, medicine, Humans, Immunology and Allergy, Research Articles, Microscopy, Sulfosalicylic acid, negative protein urine, medicine.diagnostic_test, business.industry, Biochemistry (medical), Significant difference, Public Health, Environmental and Occupational Health, Hematology, Hyaline Casts, Test (assessment), Proteinuria, Medical Laboratory Technology, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, business, Research Article, urinary microprotein |
| الوصف: | Objective To analyze the association between positive urinary casts on microscopic examination and urinary microprotein concentration in the case of negative urinary protein test results. This study also investigated the diagnostic value of urinary microprotein examination. Subjects A total of 949 samples that were analyzed with a UF‐1000i Urine Analyzer and returned cast alarm results were categorized into two groups, a positive and negative group, according to qualitative urinary protein sulfosalicylic acid test results. Then, 54 samples with negative protein test results but positive cast results according to microscopic examination were selected as the study group; 60 normal people with healthy physical examination results were selected as the control group. Both groups underwent urinary microprotein tests, including urinary microalbumin (mAlb), α1‐microglobulin (A1M), transferrin (TRU), and immunoglobulin G (IgG). T tests were used to evaluate mean differences between groups and chi‐square tests were used to calculate ratio differences between groups. Results (a) Microscopic examinations of the positive and negative protein groups revealed no statistically significant difference in cast detection rate (P = .421). (b) Among the 54 samples in the study group, 37 were found to have abnormal casts, while in the remaining 17 samples, only hyaline casts were detected. (c) The detection levels of mAlb, A1M, and IgG in the study group were significantly higher than the control group (P values Our study shown microscopic examinations of the positive and negative protein groups revealed no statistically significant difference in cast detection rate, in the case of negative dry chemical urinary protein results, the diagnosis of the presence of casts has a certain value. So urinary microprotein test should be included in the reexamination rules for routine tests for patients with negative protein results and positive casts under microscopic examination. This would improve the detection rate of casts and reduce delays in appropriate treatment. |
| تدمد: | 1098-2825 0887-8013 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40683fed2dd46db5dfc177e210c65da1 https://doi.org/10.1002/jcla.23487 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....40683fed2dd46db5dfc177e210c65da1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10982825 08878013 |
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