Introduction: Adolescent females living in agricultural areas where crops are routinely sprayed by pesticidesare expected to be environmentally exposed to pesticidesˊ health hazards partially as those occupationallyexposed. Aim of work: to assess neurobehavioral and menstrual disorders among adolescent femalesenvironmentally exposed to pesticides. Materials and methods: This was a cross-sectional study conductedon 100 pesticide exposed adolescent females who had one or more of family members are pesticidesˊ seasonalapplicators and 50 non- exposed adolescent females matched for age and education, served as controls atMenoufia governorate, Egypt; during the period of pesticide application season of cotton crop from the firstof May to the end of September 2017. A self-administered questionnaire and a series of neurobehavioral testswere administered and serum acetyl cholinesterase (AChE) activity was assessed. Results: A significant lowerAChE activity levels were detected among the exposed group compared to the controls (Mean±SD=238.49±23.83 vs 303.35±78.54 IU/L; respectively). There were significant higher mean scores of trail making test (parts1 and 2) and significant lower mean scores of (similarities test, Benton visual retention test, block design test,Santa Ana dexterity test (dominant and non-dominant hands) and Beery visuo-motor imitation test among theexposed group compared to the controls (P
