Mycobacterium tuberculosis transmission in an ethnically-diverse high incidence region in England, 2007–11
| العنوان: | Mycobacterium tuberculosis transmission in an ethnically-diverse high incidence region in England, 2007–11 |
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| المؤلفون: | Richard G. White, Adrienne Keen, Emilia Vynnycky, Shaina Khanom, Peter M. Hawkey, Ibrahim Abubakar, Jason T. Evans |
| المصدر: | BMC Infectious Diseases BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-14 (2019) |
| بيانات النشر: | BioMed Central, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Multivariate analysis, Ethnic group, Minisatellite Repeats, law.invention, MIRU-VNTR, 0302 clinical medicine, law, Risk Factors, Genotype, Ethnicity, Medicine, Cluster Analysis, 030212 general & internal medicine, Child, Molecular Epidemiology, biology, Incidence (epidemiology), Incidence, West midlands, Middle Aged, 3. Good health, Infectious Diseases, Transmission (mechanics), England, Child, Preschool, Female, Research Article, Adult, Tuberculosis, Adolescent, 030106 microbiology, Emigrants and Immigrants, Clustering, lcsh:Infectious and parasitic diseases, Mycobacterium tuberculosis, 03 medical and health sciences, Transmission, Humans, lcsh:RC109-216, Aged, Contact patterns, business.industry, Infant, Newborn, Infant, biology.organism_classification, medicine.disease, Multivariate Analysis, business, Contact tracing, Demography |
| الوصف: | Background Transmission patterns in high tuberculosis incidence areas in England are poorly understood but need elucidating to focus contact tracing. We study transmission within and between age, ethnic and immigrant groups using molecular data from the high incidence West Midlands region. Methods Isolates from culture-confirmed tuberculosis cases during 2007–2011 were typed using 24-locus Mycobacterial Interspersed Repetitive Unit-Variable Number Tandem Repeats (MIRU-VNTR). We estimated the proportion of disease attributable to recent transmission, calculated the proportion of isolates matching those from the two preceding years (“retrospectively clustered”), and identified risk factors for retrospective clustering using multivariate analyses. We calculated the ratio (RCR) between the observed and expected proportion clustered retrospectively within or between age, ethnic and immigrant groups. Results Of the 2159 available genotypes (79% of culture-confirmed cases), 34% were attributed to recent transmission. The percentage retrospectively clustered decreased from 50 to 24% for 0–14 and ≥ 65 year olds respectively (p = 0.01) and was significantly lower for immigrants than the UK-born. Higher than expected clustering occurred within 15–24 year olds (RCR: 1.4 (95% CI: 1.1–1.8)), several ethnic groups, and between UK-born or long-term immigrants with the UK-born (RCR: 1.8 (95% CI: 1.1–2.4) and 1.6 (95% CI: 1.2–1.9) respectively). Conclusions This study is the first to consider “who clusters with whom” in a high incidence area in England, laying the foundation for future whole-genome sequencing work. The higher than expected clustering seen here suggests that preferential mixing between some age, ethnic and immigrant groups occurs; prioritising contact tracing to groups with which cases are most likely to cluster retrospectively could improve TB control. Electronic supplementary material The online version of this article (10.1186/s12879-018-3585-8) contains supplementary material, which is available to authorized users. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1471-2334 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410d42dc9a9ce405cdb486ae54b31c55 http://europepmc.org/articles/PMC6323781 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....410d42dc9a9ce405cdb486ae54b31c55 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14712334 |
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