Optical Coherence Tomography and Microdialysis for Microneedle-Mediated Penetration Enhancement Study of Paeoniflorin-Loaded Ethosomes
| العنوان: | Optical Coherence Tomography and Microdialysis for Microneedle-Mediated Penetration Enhancement Study of Paeoniflorin-Loaded Ethosomes |
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| المؤلفون: | Yi Zhang, Yahua Cui, Shouying Du, Hua-Hua Li, Jie Bai, Yan-Ling Yang, Jiayi Huang, Hai-Ju Yang |
| المصدر: | Skin Pharmacology and Physiology. 34:183-193 |
| بيانات النشر: | S. Karger AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Microdialysis, Metabolic Clearance Rate, Physiology, Skin Absorption, Anti-Inflammatory Agents, Cmax, Dermatology, Administration, Cutaneous, Dosage form, chemistry.chemical_compound, Glucosides, Pharmacokinetics, Animals, Skin, Transdermal, Pharmacology, Drug Carriers, Dose-Response Relationship, Drug, Area under the curve, General Medicine, Penetration (firestop), Paeoniflorin, Rats, chemistry, Needles, Area Under Curve, Monoterpenes, Nanoparticles, Tomography, Optical Coherence, Biomedical engineering |
| الوصف: | Background: To understand the cumulative effect of topical formulations after medication, evaluate the therapeutic effect of microneedle-assisted (MN-assisted) paeoniflorin-loaded ethosomes (TGP-E), and explore the potential for deep penetration of drugs, this paper uses microdialysis to systematically study the percutaneous pharmacokinetics of TGP-E. Methods: First, optical coherence tomography (OCT) was used to study the effectiveness of microneedle puncture. Second, a microdialysis method and a UPLC-MS method for determining the amount of paeoniflorin (Pae) in dialysate were established. Finally, the transdermal pharmacokinetics of TGP-E was studied using in vivo microdialysis in rats under the above MN-assisted conditions. Results: The optimal MN-assisted conditions were obtained at a microneedle length of 500 μm, a pressure of 3 N, and an action time of 3 min. The pharmacokinetic results demonstrated that the maximum drug concentration (Cmax) and the area under the curve (AUC) of the TGP-E gel were higher than the TGP-saline solution gel, and the mean retention time was lower. These indicated that microneedle can promote the entry of the ethosomes into the skin for in vivo experiments and greatly improve the possibility of deep penetration of the water-soluble Pae. Conclusion: Therefore, the microneedle-ethosomes delivery system is a more ideal means for promoting the deep penetration of Pae. These findings may provide a reference for the combination of multiple penetration-enhancement ways to promote drug absorption, and also provide a new insight to realize the development of novel, safe, and more effective dosage forms and administration routes of drugs. |
| تدمد: | 1660-5535 1660-5527 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41134ee4e521e5f470119fa233e1e97d https://doi.org/10.1159/000514321 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....41134ee4e521e5f470119fa233e1e97d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16605535 16605527 |
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