Boswellic Acids as Promising Leads in Drug Development against Alzheimer’s Disease
| العنوان: | Boswellic Acids as Promising Leads in Drug Development against Alzheimer’s Disease |
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| المؤلفون: | Hossein Haghaei, Mohammad-Reza Rashidi, Seyed Rafie Aref Hosseini, Saeed Karima, Somaieh Soltani |
| المصدر: | Pharmaceutical Sciences, Vol 27, Iss 1, Pp 14-31 (2021) |
| بيانات النشر: | Maad Rayan Publishing Company, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | In silico, education, lcsh:RS1-441, Pharmaceutical Science, Pharmacology, medicine.disease_cause, lcsh:Pharmacy and materia medica, 03 medical and health sciences, 0302 clinical medicine, disease-modifying therapeutics, In vivo, boswellic acids, Medicine, General Pharmacology, Toxicology and Pharmaceutics, Boswellia, 030304 developmental biology, 0303 health sciences, biology, multi-target drug, Drug discovery, business.industry, plant derived scaffolds, alzheimer’s disease, Biological activity, biology.organism_classification, In vitro, Drug development, business, 030217 neurology & neurosurgery, Oxidative stress |
| الوصف: | Biological activity of Boswellia extract (BE) has been attributed to its main active ingredients; i.e. Boswellic acids (BAs). BE/BAs possess a promising therapeutic potential in neurodegenerative disorders; including Alzheimer's disease (AD). The multifactorial nature of AD pathophysiology necessitates the development of the disease-modifying agents (DMA). Recent multi-targeting approaches for the DMAs development have brought more attention to the plant-derived compounds regarding their better human compatibility because of their biologic origin. This review addresses the current knowledge on the anti-AD activity of BE/BAs based on the available in silico, in vitro, in vivo studies and clinical trials. The contribution of BE/BAs in inflammatory pathways, Tau and β-amyloid proteins, microtubule functions, oxidative stress, cholinesterase and diabetes/insulin pathways involved in AD have been discussed. BAs efficacy in different AD-related pathways has been confirmed in vitro and in vivo. They can be considered as valuable scaffold/lead compounds for multi-targeted DMAs in anti-AD drug discovery and development. |
| تدمد: | 2383-2886 1735-403X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41147bcf035ea40a13dc1e7ef8093afd https://doi.org/10.34172/ps.2020.25 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....41147bcf035ea40a13dc1e7ef8093afd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23832886 1735403X |
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