Synthesis and Antiproliferative Evaluation of Novel Longifolene-Derived Tetralone Derivatives Bearing 1,2,4-Triazole Moiety
| العنوان: | Synthesis and Antiproliferative Evaluation of Novel Longifolene-Derived Tetralone Derivatives Bearing 1,2,4-Triazole Moiety |
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| المؤلفون: | Wengui Duan, Xia-Ping Zhu, Qing-Min Li, Guishan Lin, Shun-Zhong Lu, Fang-Yao Li |
| المصدر: | Molecules Volume 25 Issue 4 Molecules, Vol 25, Iss 4, p 986 (2020) |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | antiproliferative activity, Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, synthesis, Stereochemistry, Pharmaceutical Science, 010402 general chemistry, 01 natural sciences, Article, Analytical Chemistry, lcsh:QD241-441, chemistry.chemical_compound, 1,2,4-triazole, lcsh:Organic chemistry, longifolene-derived tetralone, Neoplasms, Drug Discovery, Spectroscopy, Fourier Transform Infrared, Tetralone, Moiety, Humans, MTT assay, Physical and Theoretical Chemistry, Cell Proliferation, Tetralones, Sulfonyl, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Organic Chemistry, 1,2,4-Triazole, Hep G2 Cells, Triazoles, 0104 chemical sciences, Chemistry (miscellaneous), Cell culture, MCF-7 Cells, Molecular Medicine, Longifolene, Sesquiterpenes, Human cancer |
| الوصف: | Seventeen novel 2-(5-amino-1-(substituted sulfonyl)-1H-1,2,4-triazol-3-ylthio)-6- isopropyl-4,4-dimethyl-3,4-dihydronaphthalen-1(2H)-one compounds were synthesized from the abundant and naturally renewable longifolene and their structures were confirmed by FT-IR, NMR, and ESI-MS. The in vitro cytotoxicity of the synthesized compounds was evaluated by standard MTT assay against five human cancer cell lines, i.e., T-24, MCF-7, HepG2, A549, and HT-29. As a result, compounds 6d, 6g, and 6h exhibited better and more broad-spectrum anticancer activity against almost all the tested cancer cell lines than that of the positive control, 5-FU. Some intriguing structure&ndash activity relationships were found and are discussed herein by theoretical calculation. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4137283ac097676582ad415b126ce212 http://europepmc.org/articles/PMC7070458 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4137283ac097676582ad415b126ce212 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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