RISK FACTORS FOR OSTEOPOROSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS (PRELIMINARY RESULTS ACCORDING TO THE MATERIALS OF THE MULTICENTER PROGRAM «OSTEOPOROSIS IN RHEUMATOID ARTHRITIS: DIAGNOSIS, RISK FACTORS, FRACTURES, TREATMENT»)
| العنوان: | RISK FACTORS FOR OSTEOPOROSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS (PRELIMINARY RESULTS ACCORDING TO THE MATERIALS OF THE MULTICENTER PROGRAM «OSTEOPOROSIS IN RHEUMATOID ARTHRITIS: DIAGNOSIS, RISK FACTORS, FRACTURES, TREATMENT») |
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| المؤلفون: | A E Sizikov, N. V. Dyomin, L. Alekseeva, Nasonov El, T. Yu. Bolshakova, E S Zhugrova, M. M. Podvorotova, E. V. Petrova, E A Taskina, I. Dydykina, Polina Dydykina, V. N. Sorotskaya, T. Raskina, I. B. Vinogradova, A. V. Smirnov, D Peshekhonov, A A Muradyants |
| المصدر: | Научно-практическая ревматология, Vol 52, Iss 4, Pp 393-397 (2014) |
| بيانات النشر: | IMA-PRESS LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | rheumatoid arthritis, medicine.medical_specialty, business.industry, Immunology, Osteoporosis, Diseases of the musculoskeletal system, medicine.disease, osteoporosis, Rheumatology, RC925-935, Internal medicine, Rheumatoid arthritis, Immunology and Allergy, Medicine, risk factors, In patient, business |
| الوصف: | Osteoporosis (OP) in rheumatoid arthritis (RA) is 2–3 times more common than in the population; however, the data on the risk factors (RFs) of OP in this disease are ambiguous.Objective: to study RFs for OP in RA within the framework of the multicenter program “Osteoporosis in rheumatoid arthritis: Diagnosis, risk factors, fractures, treatment”.Subjects and methods. The trial enrolled 261 women (mean age 56.7±11.4 years) with RA; of them 151 (59%) patients were found to have OP (Group 1) and 107 (41%) were not (Group 2). All the patients underwent unified clinical, laboratory, and instrumental examination.Results. Comparison of the patients with and without OP showed that the women with OP were older (59.5±10.8 and 52.9±11.2 years, respectively; p < 0.01) had longer RA duration (14.5±9.2 and 11±8.0 years; p < 0.01), higher Health Assessment Questionnaire (HAQ) functional disability index scores (1.7±0.8 and 1.4±0.9; p < 0.01), higher C-reactive protein (CRP) levels (13.5 [7; 31] and 11 [2,7; 26] mg/l; p < 0.01); a larger number of erosions (49 [11; 90] and 8 [1;36]; p < 0.01), and a more marked joint space narrowing (112 [90; 131] and 77 [51; 102]; p < 0.01). The women with OP received longer (72 [26.5; 120] and 48 [11; 79.5] months; p < 0.01) and more frequently glucocorticoids (GC) orally (65.6 and 38.3%; p < 0.01) and as pulse therapy (41.2 and 20.4%; p < 0.01), had a larger cumulative dose (14.4 [5.4; 24.2] and 7.2 [1.5; 14.4] g; p < 0.01) and a larger GC dose at their examination (6.0 [4.0; 8,0] and 5.0 [4.0; 6.0]mg/day, respectively; p = 0.05).Conclusion. The presence of OP in RA correlates with age, RA duration, articular dysfunction, CRP levels, X-ray change magnitude, hormone therapy duration, and a cumulative GC dose. |
| اللغة: | Russian |
| تدمد: | 1995-4492 1995-4484 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4141691eccb6a65e95ce4474ac153967 https://rsp.mediar-press.net/rsp/article/view/1960 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4141691eccb6a65e95ce4474ac153967 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19954492 19954484 |
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