An Inverse Correlation of Human Peripheral Blood Regulatory T Cell Frequency with the Disease Activity of Ulcerative Colitis
| العنوان: | An Inverse Correlation of Human Peripheral Blood Regulatory T Cell Frequency with the Disease Activity of Ulcerative Colitis |
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| المؤلفون: | Kazuhiko Nakamura, Yousuke Kitamura, Yuzuru Araki, Teppei Kabemura, Hajime Nawata, Naohiko Harada, Makoto Takahashi, Yoshiharu Chijiiwa, Takahiro Mizutani, Kuniomi Honda |
| المصدر: | Digestive Diseases and Sciences. 51:677-686 |
| بيانات النشر: | Springer Science and Business Media LLC, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Adult, CD4-Positive T-Lymphocytes, Male, Interleukin 2, Adolescent, Physiology, Regulatory T cell, T cell, Molecular Sequence Data, chemical and pharmacologic phenomena, Sensitivity and Specificity, Severity of Illness Index, T-Lymphocytes, Regulatory, Inflammatory bowel disease, TCIRG1, Interleukin 21, Reference Values, medicine, Humans, IL-2 receptor, Cells, Cultured, Probability, Base Sequence, Reverse Transcriptase Polymerase Chain Reaction, business.industry, Gastroenterology, FOXP3, Receptors, Interleukin-2, hemic and immune systems, Middle Aged, medicine.disease, medicine.anatomical_structure, Case-Control Studies, Immunology, Disease Progression, Leukocyte Common Antigens, Colitis, Ulcerative, Female, business, Biomarkers, medicine.drug |
| الوصف: | Evidence suggests that CD4+CD25+ regulatory T cells play a crucial role in the suppression of intestinal inflammation. However, their role in the suppression of inflammatory bowel disease has not yet been addressed. We examined the proportion of regulatory T cells in inflammatory bowel disease. First, we isolated CD4+CD45RO+CD25+ T cells from the peripheral blood of healthy persons and showed that these cells suppressed T cell proliferation profoundly and expressed FoxP3 abundantly, revealing that they are regulatory cells. Then the proportion of CD45RO+CD25+ in peripheral blood CD4+ T cells was analyzed in patients and healthy controls by flow cytometry. CD4+CD45RO+CD25+ T cell frequency was significantly lower in active ulcerative colitis than in the control and inactive ulcerative colitis. CD4+CD45RO+CD25+ T cell frequency was inversely correlated with the clinical and endoscopic severity of ulcerative colitis. These results suggest that a deficiency of regulatory T cells is associated with the progression of ulcerative colitis. |
| تدمد: | 1573-2568 0163-2116 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414846bbeaa37584e95f3f0e859ffbaf https://doi.org/10.1007/s10620-006-3191-2 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....414846bbeaa37584e95f3f0e859ffbaf |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15732568 01632116 |
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