Unraveling the mechanisms of inhibition of silver‐doped bioactive glass–ceramic particles
| العنوان: | Unraveling the mechanisms of inhibition of silver‐doped bioactive |
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| المؤلفون: | Natalia Pajares‐Chamorro, Josh M. Lensmire, Neal D. Hammer, Jonathan W. Hardy, Xanthippi Chatzistavrou |
| المصدر: | Journal of Biomedical Materials Research Part A. 111:975-994 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Biomaterials, Metals and Alloys, Biomedical Engineering, Ceramics and Composites |
| الوصف: | Infections are a major concern in orthopedics. Antibacterial agents such as silver ions are of great interest as broad-spectrum biocides and have been incorporated into bioactive glass-ceramic particles to control the release of ions within a therapeutic concentration and provide tissue regenerative properties. In this work, the antibacterial capabilities of silver-doped bioactive glass (Ag-BG) microparticles were explored to reveal the unedited mechanisms of inhibition against methicillin-resistant Staphylococcus aureus (MRSA). The antibacterial properties were not limited to the delivery of silver ions but rather a combination of antibacterial degradation by-products. For example, nano-sized debris punctured holes in bacteria membranes, osmotic effects, and reactive oxygen species causing oxidative stress and almost 40% of the inhibition. Upon successive Ag-BG treatments, MRSA underwent phenotypic and genomic mutations which were not only insufficient to develop resistance but instead, the clones became more sensitive as the treatment was re-delivered. Additionally, the unprecedented restorative functionality of Ag-BG allowed the effective use of antibiotics that MRSA resists. The synergy mechanism was mainly identified for combinations targeting cell-wall activity and their action was proven in biofilm-like and virulent conditions. Unraveling these mechanisms may offer new insights into how to tailor healthcare materials to prevent or debilitate infections and join the fight against antibiotic resistance in clinical cases. |
| تدمد: | 1552-4965 1549-3296 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418a3549b3500a5ee2b0148a08377a26 https://doi.org/10.1002/jbm.a.37482 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....418a3549b3500a5ee2b0148a08377a26 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15524965 15493296 |
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