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Myocardial function at the early phase of traumatic brain injury: a prospective controlled study

التفاصيل البيبلوغرافية
العنوان: Myocardial function at the early phase of traumatic brain injury: a prospective controlled study
المؤلفون: Jean François Payen, Stéphane Nottin, Guillaume Walther, Pierre Bouzat, Adrien Cuisinier, Claire Maufrais
المساهمون: Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Avignon Université (AU), EA4278 Laboratoire de Pharm-Ecologie Cardiovasculaire (LaPEC), Neuro-imagerie fonctionnelle et métabolique (ANTE-INSERM U836, équipe 5), Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)
المصدر: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, BioMed Central, 2016, 24, pp.129. ⟨10.1186/s13049-016-0323-3⟩
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, BioMed Central, 2016, 24 (1), ⟨10.1186/s13049-016-0323-3⟩
بيانات النشر: HAL CCSD, 2016.
سنة النشر: 2016
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Time Factors, Adolescent, Traumatic brain injury, [SDV]Life Sciences [q-bio], Diastole, Poison control, Speckle tracking echocardiography, Critical Care and Intensive Care Medicine, Ventricular Function, Left, Ventricular Dysfunction, Left, Young Adult, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, Brain Injuries, Traumatic, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Single-Blind Method, Prospective Studies, Prospective cohort study, ComputingMilieux_MISCELLANEOUS, Original Research, Ejection fraction, business.industry, Stroke Volume, 030208 emergency & critical care medicine, Retrospective cohort study, Middle Aged, Prognosis, medicine.disease, 3. Good health, Surgery, Echocardiography, Case-Control Studies, Cardiology, Emergency Medicine, Female, Isovolumic relaxation time, business, 030217 neurology & neurosurgery, Follow-Up Studies
الوصف: Background The concept of brain-heart interaction has been described in several brain injuries. Traumatic brain injury (TBI) may also lead to cardiac dysfunction but evidences are mainly based upon experimental and clinical retrospective studies. Methods We conducted a prospective case-control study in a level I trauma center. Twenty consecutive adult patients with severe TBI were matched according to age and gender with 20 control patients. The control group included adult patients undergoing a general anesthesia for a peripheral trauma surgery. Conventional and Speckle Tracking Echocardiography (STE) was performed within the first 24 post-traumatic hours in the TBI group and PRE/PER-operative in the control group. The primary endpoint was the left ventricle ejection fraction (LVEF) measured by the Simpson’s method. Secondary endpoints included the diastolic function and the STE analysis. Results We found similar LVEF between the TBI group and the PER-operative control group (61 % [56–76]) vs. 62 % [52–70]). LV morphological parameters and the systolic function were also similar between the two groups. Regarding the diastolic function, the isovolumic relaxation time was significantly higher in the TBI cohort (125 s [84–178] versus 107 s [83–141], p = 0.04), suggesting a subclinical diastolic dysfunction. Using STE parameters, we observed a trend toward higher strains in the TBI group but only the apical circumferential strain and the basal rotation reached statistical significance. STE-derived parameters of the diastolic function tended to be lower in TBI patients. Discussion No systematic myocardial depression was found in a cohort of severe TBI patients. Conclusions STE revealed a correct adaptation of the left systolic function, while the diastolic function slightly impaired. Trial registration NCT02380482 Electronic supplementary material The online version of this article (doi:10.1186/s13049-016-0323-3) contains supplementary material, which is available to authorized users.
اللغة: English
تدمد: 1757-7241
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41cc385ce0e75da639a2b946a5a0b031
https://hal.archives-ouvertes.fr/hal-02152123/document
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....41cc385ce0e75da639a2b946a5a0b031
قاعدة البيانات: OpenAIRE
الوصف
تدمد:17577241