Australian experience with total pancreatectomy with islet autotransplantation to treat chronic pancreatitis
| العنوان: | Australian experience with total pancreatectomy with islet autotransplantation to treat chronic pancreatitis |
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| المؤلفون: | David J. Torpy, Wayne J. Hawthorne, D Jane Holmes-Walker, Christine Russell, Thomas Loudovaris, Lindy Williams, Toni Radford, Tristan J. Bampton, Gordon Thomas, Pamela E. Macintyre, H. E. Thomas, Jennifer J Couper, C. Etherton, Natasha M. Rogers, P. J. O'connell, John W. Chen, Paul Z. Benitez-Aguirre, Denghao Wu, R. L. T. Couper, Lyle J. Palmer, Henry Pleass, Chris Drogemuller, Patricia Anderson, Eu Ling Neo, Thomas W.H. Kay, Sanjeev Khurana, P. Toby Coates |
| المصدر: | ANZ journal of surgeryReferences. 91(12) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.medical_treatment, Transplantation, Autologous, 03 medical and health sciences, 0302 clinical medicine, Pancreatectomy, Interquartile range, Internal medicine, Diabetes mellitus, Pancreatitis, Chronic, Medicine, Humans, Pain Management, Hereditary pancreatitis, geography, geography.geographical_feature_category, business.industry, Australia, General Medicine, medicine.disease, Islet, Autotransplantation, Transplantation, 030220 oncology & carcinogenesis, Pancreatitis, 030211 gastroenterology & hepatology, Surgery, business |
| الوصف: | BACKGROUND This study aimed to describe the clinical outcomes of total pancreatectomy with islet autotransplantation (TP-IAT) in Australia. METHODS Individuals selected for TP-IAT surgery according to the Minnesota Criteria (Appendix) without evidence of diabetes were evaluated including time to transplantation from pancreatectomy, islet numbers infused and post-transplantation HbA1c, C-peptide, total daily insulin and analgesic requirement. RESULTS Sixteen individuals underwent TP-IAT from Australia and New Zealand between 2010 and 2020. Two recipients are deceased. The median islet equivalents/kg infused was 4244 (interquartile range (IQR) 2290-7300). The median C-peptide 1 month post-TP-IAT was 384 (IQR 210-579) pmol/L and at median 29.5 (IQR 14.5-46.5) months from transplant was 395 (IQR 139-862) pmol/L. Insulin independence was achieved in eight of 15 (53.3%) surviving recipients. A higher islet equivalents transplanted was most strongly associated with the likelihood of insulin independence (P |
| تدمد: | 1445-2197 2290-7300 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424134fa76c385f839ef1790b0d1e294 https://pubmed.ncbi.nlm.nih.gov/33956377 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....424134fa76c385f839ef1790b0d1e294 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14452197 22907300 |
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