OXA-900, a Novel OXA Sub-Family Carbapenemase Identified in Citrobacter freundii, Evades Detection by Commercial Molecular Diagnostics Tests
| العنوان: | OXA-900, a Novel OXA Sub-Family Carbapenemase Identified in Citrobacter freundii, Evades Detection by Commercial Molecular Diagnostics Tests |
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| المؤلفون: | Shirin Abramov, Hadas Kon, David Schwartz, Mor Nadia Lurie-Weinberger, Erica Pinco, Nadya Rakovitsky, Jonathan Lellouche, Reut Rov, Yehuda Carmeli, Sammy Frenk |
| المصدر: | Microorganisms Volume 9 Issue 9 Microorganisms, Vol 9, Iss 1898, p 1898 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Microbiology (medical), Carbapenem, QH301-705.5, Biology, Microbiology, Shewanella, chemistry.chemical_compound, carbapenemase, Enterobacterales, Virology, medicine, polycyclic compounds, Biology (General), Gene, Cloning, Genetics, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Molecular diagnostics, biology.organism_classification, β-lactamase, blaOXA-48-like, Citrobacter freundii, chemistry, bacteria, DNA, medicine.drug |
| الوصف: | Using whole-genome sequencing and cloning of the target gene, we identified blaOXA-900 carbapenemase, a novel blaOXA belonging to a distant and distinct sub-family of blaOXA-48-like. The plasmid-mediated gene was identified in a C. freundii isolate with elevated carbapenem MICs that evaded detection by commercial DNA-based methods. The novel gene, an OXA-48 family carbapenem-hydrolyzing class D β-lactamase, OXA-900, likely originates from marine environmental Shewanella. Since this plasmid-mediated gene has entered a member of the Enterobacterales and evades detection by commonly used tests, it may gain wide dissemination among Enterobacterales. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2076-2607 |
| DOI: | 10.3390/microorganisms9091898 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429b7ccbeb182bfea063fa585cd78036 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....429b7ccbeb182bfea063fa585cd78036 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20762607 |
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| DOI: | 10.3390/microorganisms9091898 |