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The impact of obstructive sleep apnea on homocysteine and carotid remodeling in metabolic syndrome

التفاصيل البيبلوغرافية
العنوان: The impact of obstructive sleep apnea on homocysteine and carotid remodeling in metabolic syndrome
المؤلفون: Patrick Levy, V. Ducros, Renaud Tamisier, Denis Monneret, Patrice Faure, C. Garrel, J.-P. Baguet, Jean-Louis Pépin
المصدر: Respiratory Physiology & Neurobiology. 180:298-304
بيانات النشر: Elsevier BV, 2012.
سنة النشر: 2012
مصطلحات موضوعية: Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Homocysteine, Physiology, Polysomnography, Population, Blood Pressure, Context (language use), Isoprostanes, Dinoprost, Carotid Intima-Media Thickness, Antioxidants, chemistry.chemical_compound, Tandem Mass Spectrometry, Internal medicine, Humans, Medicine, Sulfhydryl Compounds, Risk factor, education, Chromatography, High Pressure Liquid, Metabolic Syndrome, Sleep Apnea, Obstructive, education.field_of_study, medicine.diagnostic_test, business.industry, General Neuroscience, Sleep apnea, Middle Aged, Atherosclerosis, medicine.disease, Lipids, respiratory tract diseases, Obstructive sleep apnea, Oxidative Stress, Carotid Arteries, Endocrinology, chemistry, Cardiology, Female, Endothelium, Vascular, Metabolic syndrome, Arousal, business, Oxidation-Reduction
الوصف: Obstructive sleep apnea (OSA) and metabolic syndrome (MetS) are associated with increased cardiovascular morbidity and mortality. Increased homocysteine is suggested as an independent risk factor for atherosclerosis and cardiovascular disease but remains disputed in OSA. We assessed polysomnography, carotid intima-media thickness (CIMT) and biology in 35 MetS patients, according to the presence (OSA+MetS; n=26) or the absence of OSA (MetS; n=9). In OSA+MetS patients, homocysteine levels were increased compared to MetS subjects (12.8 ± 3.8 vs. 9.5 ± 2.5 μmol/L; P=0.026). In the whole population, homocysteine correlated with apnea-hypopnea index (AHI) (r=0.522; P=0.001) and CIMT (r=0.376; P=0.026). Homocysteine was negatively correlated with plasma thiols (r=-0.406; P=0.017) and positively with urinary 15-F2t-isoprostanes (r=0.347; P=0.044). Multivariate regression analysis revealed that AHI (β=0.559; P
تدمد: 1569-9048
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cb27e144617accc1278afa472a63c0
https://doi.org/10.1016/j.resp.2011.12.009
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....42cb27e144617accc1278afa472a63c0
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15699048