RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena
| العنوان: | RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena |
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| المؤلفون: | Wei Miao, Lifang Feng, Cédric Feschotte, Aurélie Kapusta, Shan Gao, Xiaolu Zhao, Robert S. Coyne, Yalan Sheng, Xiao Chen, Jie Xiong, Wentao Yang, Wen Dui, Yifan Liu, Fengbiao Mao |
| المصدر: | Genes & Development. 33:348-364 |
| بيانات النشر: | Cold Spring Harbor Laboratory, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Transcriptional Activation, Transposable element, RNA, Untranslated, Mutant, Protozoan Proteins, Polycomb-Group Proteins, Biology, Germline, Epigenesis, Genetic, Tetrahymena thermophila, 03 medical and health sciences, 0302 clinical medicine, RNA interference, Genetics, Gene silencing, Gene Silencing, RNA, Messenger, Psychological repression, 030304 developmental biology, 0303 health sciences, fungi, Tetrahymena, Non-coding RNA, biology.organism_classification, Cell biology, 030220 oncology & carcinogenesis, Mutation, DNA Transposable Elements, RNA Interference, Research Paper, Developmental Biology |
| الوصف: | RNAi and Polycomb repression play evolutionarily conserved and often coordinated roles in transcriptional silencing. Here, we show that, in the protozoan Tetrahymena thermophila, germline-specific internally eliminated sequences (IESs)—many related to transposable elements (TEs)—become transcriptionally activated in mutants deficient in the RNAi-dependent Polycomb repression pathway. Germline TE mobilization also dramatically increases in these mutants. The transition from noncoding RNA (ncRNA) to mRNA production accompanies transcriptional activation of TE-related sequences and vice versa for transcriptional silencing. The balance between ncRNA and mRNA production is potentially affected by cotranscriptional processing as well as RNAi and Polycomb repression. We posit that interplay between RNAi and Polycomb repression is a widely conserved phenomenon, whose ancestral role is epigenetic silencing of TEs. |
| تدمد: | 1549-5477 0890-9369 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cd682b15201dd12f8fa98d8a477743 https://doi.org/10.1101/gad.320796.118 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....42cd682b15201dd12f8fa98d8a477743 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15495477 08909369 |
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