When Functionalization of PLA Surfaces Meets Thiol−Yne Photochemistry: Case Study with Antibacterial PolyaspartamideDerivatives
العنوان: | When Functionalization of PLA Surfaces Meets Thiol−Yne Photochemistry: Case Study with Antibacterial PolyaspartamideDerivatives |
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المؤلفون: | SARDO, Carla, TRIOLO, Daniela, GIAMMONA, Gaetano, CAVALLARO, Gennara, Nottelet, B, Flaud, V, Garric, X, Lavigne,JP, Coudane |
المساهمون: | Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli studi di Palermo - University of Palermo, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Istituto di BioFisica [Palermo] (IBF), Consiglio Nazionale delle Ricerche (CNR), Virulence bactérienne et maladies infectieuses (VBMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Fondazione Cariplo (Project 2010-0454), MIUR (PRIN 2010-2011, 20109P1MH2_003), Sardo, C, Nottelet, B, Triolo, D, Giammona, G, Flaud, V, Garric, X, Lavigne,JP, Cavallaro, G, Coudane |
المصدر: | Biomacromolecules Biomacromolecules, American Chemical Society, 2014, 15 (11), pp.4351-4362. ⟨10.1021/bm5013772⟩ |
بيانات النشر: | HAL CCSD, 2014. |
سنة النشر: | 2014 |
مصطلحات موضوعية: | Polymers and Plastics, Polyaspartamide copolymer, Photochemistry, Surface Properties, Polyesters, PLA surfaces, Bioengineering, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Cell Line, Biomaterials, Mice, Materials Chemistry, Copolymer, Organic chemistry, Animals, Sulfhydryl Compounds, Polyaspartamide copolymers, chemistry.chemical_classification, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Biofilm, 021001 nanoscience & nanotechnology, Grafting, Fluorescence, Combinatorial chemistry, In vitro, 0104 chemical sciences, Anti-Bacterial Agents, chemistry, Covalent bond, Settore CHIM/09 - Farmaceutico Tecnologico Applicativo, Thiol, Surface modification, 0210 nano-technology, Peptides |
الوصف: | International audience; In this work we wish to report on the covalent functionalization of polylactide (PLA) surfaces by photoradical thiol–yne to yield antibacterial surfaces. At first, hydrophilic and hydrophobic thiol fluorescent probes are synthesized and used to study and optimize the conditions of ligation on alkyne-PLA surfaces. In a second part, a new antibacterial polyaspartamide copolymer is covalently grafted. The covalent surface modification and the density of surface functionalization are evaluated by SEC and XPS analyses. No degradation of PLA chains is observed, whereas covalent grafting is confirmed by the presence of S2p and N1s signals. Antiadherence and antibiofilm activities are assessed against four bacterial strains, including Gram-negative and Gram-positive bacteria. A strong activity is observed with adherence reduction factors superior to 99.98% and biofilm formation decreased by 80%. Finally, in vitro cytocompatibility tests of the antibacterial surfaces are performed with L929 murine fibroblasts and show cell viability without promoting proliferation. |
اللغة: | English |
تدمد: | 1525-7797 1526-4602 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e616ea75cbf521ddfee9af8bf77e01 https://hal.archives-ouvertes.fr/hal-01091018 |
حقوق: | CLOSED |
رقم الأكسشن: | edsair.doi.dedup.....42e616ea75cbf521ddfee9af8bf77e01 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 15257797 15264602 |
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