PTEN: An Emerging Potential Target for Therapeutic Intervention in Respiratory Diseases
| العنوان: | PTEN: An Emerging Potential Target for Therapeutic Intervention in Respiratory Diseases |
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| المؤلفون: | Bangrong Cai, Liu Yang, Young Do Jung, Ying Zhang, Xinguang Liu, Peng Zhao, Jiansheng Li |
| المصدر: | Oxidative Medicine and Cellular Longevity. 2022:1-26 |
| بيانات النشر: | Hindawi Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Inflammation, Phosphatidylinositol 3-Kinases, Pulmonary Disease, Chronic Obstructive, Aging, Acute Lung Injury, PTEN Phosphohydrolase, Humans, Cell Biology, General Medicine, Biochemistry, Asthma, Idiopathic Pulmonary Fibrosis |
| الوصف: | Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a potent tumor suppressor that regulates several key cellular processes, including proliferation, survival, genomic integrity, migration, and invasion, via PI3K-dependent and independent mechanisms. A subtle decrease in PTEN levels or catalytic activity is implicated not only in cancer but also in a wide spectrum of other diseases, including various respiratory diseases. A systemic overview of the advances in the molecular and cellular mechanisms of PTEN involved in the initiation and progression of respiratory diseases may offer novel targets for the development of effective therapeutics for the treatment of respiratory diseases. In the present review, we highlight the novel findings emerging from current research on the role of PTEN expression and regulation in airway pathological conditions such as asthma/allergic airway inflammation, pulmonary hypertension (PAH), chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and other acute lung injuries (ALI). Moreover, we discuss the clinical implications of PTEN alteration and recently suggested therapeutic possibilities for restoration of PTEN expression and function in respiratory diseases. |
| تدمد: | 1942-0994 1942-0900 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42eb3ed468ea8b9ee456eb139ced0e97 https://doi.org/10.1155/2022/4512503 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....42eb3ed468ea8b9ee456eb139ced0e97 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19420994 19420900 |
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