أعرض في EDS

Neonatal alloimmune thrombocytopenia caused by anti-HPA antibodies in pregnant Chinese women: a study protocol for a multicentre, prospective cohort trial

التفاصيل البيبلوغرافية
العنوان: Neonatal alloimmune thrombocytopenia caused by anti-HPA antibodies in pregnant Chinese women: a study protocol for a multicentre, prospective cohort trial
المؤلفون: Tingting Xie, Jun Wen, Jun Zhang, Yonggeng Chen, Xianjun Ma, Fenghua Liu, Yinlan Kang, Beizhan Yan, Xiaojing Zeng, Li Chen, Wen Yin, Xiaochuan Song, Yaming Wei, Meiying Rao, Xiangfu Liu, Genling Zhang, Zhongjun Li, Lei Zhang, Huang Yuanshuai, Xiaojuan Li, Qiushi Wang, Peng Wang, Jiang Wu, Yongjun Wang, Sun Bo, Yi Guo, Tiemei Liu, Zhiwei Liu
المصدر: BMC Pregnancy and Childbirth, Vol 17, Iss 1, Pp 1-5 (2017)
BMC Pregnancy and Childbirth
بيانات النشر: BMC, 2017.
سنة النشر: 2017
مصطلحات موضوعية: China, medicine.medical_specialty, endocrine system, Genotype, Population, Reproductive medicine, Gestational Age, 030204 cardiovascular system & hematology, lcsh:Gynecology and obstetrics, Neonatal Alloimmune thrombocytopenia, Study Protocol, 03 medical and health sciences, Fetus, 0302 clinical medicine, Asian People, Clinical Protocols, Isoantibodies, Pregnancy, Risk Factors, medicine, Humans, Antigens, Human Platelet, Prospective Studies, education, Prospective cohort study, lcsh:RG1-991, education.field_of_study, biology, Human leukocyte antigen, Obstetrics, business.industry, Incidence (epidemiology), Infant, Newborn, Obstetrics and Gynecology, Gestational age, medicine.disease, Human platelet antigen, Thrombocytopenia, Neonatal Alloimmune, Immunology, Neonatal alloimmune thrombocytopenia, biology.protein, Female, Pregnancy Trimesters, Antibody, business, 030215 immunology
الوصف: Background Neonatal alloimmune thrombocytopenia (NAIT), caused by maternal antibodies raised against alloantigens carried on foetal platelets, is a very common haematological abnormality in newborns worldwide. However, baseline data on NAIT in China are lacking. Therefore, this study seeks to explore the incidence of alloantibody against the human platelet antigen (HPA) in pregnant women and its associations with NAIT in China. Methods A multicentre, prospective cohort study design will be used, and 55,497 pregnant women will be recruited for the first screening of the anti-HPA antibody at 12 to 28 weeks of gestational age. Subjects who are positive in the first screening for the anti-HPA antibody will be included in the exposure group. Re-tests of the antibody titre, antigen-specificity and genotyping of HPA and HLA will be conducted during admission. A ratio of 1:1 paired individuals with the same ethnicity and parity but testing negative for the anti-HPA antibody will be randomly selected to be included in the non-exposure group. NAIT will be diagnosed in the newborns on day one of the birth. The HPA of the neonates in the exposure group will also be genotyped by sequencing. Associations of maternal HLA with the occurrence of the anti-HPA antibody and correlation of the severity of NAIT with the titre of the anti-HPA antibody will be further analysed. Discussion The study is expected to provide baseline data on NAIT in China. Besides, we hope to find out a population who expresses particular HLA molecules has significant higher risk of HPA alloimmunization in Chinese individuals. We also hope to find a Chinese-specific cut-off antibody titre for the prediction of the severity of NAIT and to provide a means to evaluate the necessity of antenatal treatment. Trial registration ClinicalTrials.gov: NCT02934906 (date registered: 13.10.2016).
اللغة: English
تدمد: 1471-2393
0293-4906
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ffffd81a619b4a50a698fad4f8d0d5
http://link.springer.com/article/10.1186/s12884-017-1453-y
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....42ffffd81a619b4a50a698fad4f8d0d5
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14712393
02934906