A prospective study of the prognostic value of cathepsin D levels in breast cancer cytosol
| العنوان: | A prospective study of the prognostic value of cathepsin D levels in breast cancer cytosol |
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| المؤلفون: | Henri Rochefort, Thierry Maudelonde, Henri Pujol, Pascal Pujol, Jean-Pierre Daurès, Jean-Paul Brouillet, Philippe Rouanet |
| المصدر: | Cancer. 71:2006-2012 |
| بيانات النشر: | Wiley, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Adult, Oncology, Cancer Research, medicine.medical_specialty, Pathology, Mammary gland, Cathepsin D, Breast Neoplasms, Metastasis, Cytosol, Breast cancer, Internal medicine, medicine, Adjuvant therapy, Humans, Prospective Studies, Prospective cohort study, Aged, Analysis of Variance, Univariate analysis, business.industry, Middle Aged, Progesterone Receptor Status, Prognosis, medicine.disease, Survival Rate, medicine.anatomical_structure, Lymphatic Metastasis, Female, business |
| الوصف: | BACKGROUND Cathepsin D is a lysosomal protease overexpressed and abnormally secreted in most breast cancer cells. Several retrospective clinical studies have shown that cathepsin D is an independent prognostic factor in breast cancer that is associated with a higher risk of recurrence and a shorter overall survival. METHODS To the authors' knowledge, this is the first prospective study in which the prognostic value of cathepsin D was studied in 123 patients with primary breast cancer who were followed for 5 years between March 1985 and December 1990. Cathepsin D concentrations in breast cancer cytosol were measured using a solid-phase sandwich immunoenzymatic assay. The most significant prognostic factors were identified by multivariate analysis using the Cox proportional-hazards method. RESULTS The median value of cathepsin D was 20.8 pmol/mg of protein, which was approximately half than the median value found in subsequent assays done using a commercially available kit and reported in most retrospective studies. The cathepsin D status or level was correlated only with axillary lymph node involvement. A univariate analysis showed that high levels of cathepsin D (> 20 pmol/mg of protein) were correlated with a higher risk of recurrence and a shorter overall survival (P < 0.01 and P < 0.03, respectively). Using multivariate analysis, a high cathepsin D level, a negative progesterone receptor status, and lymph node involvement were the most important factors for predicting relapse-free survival (P = 0.02, P < 0.01, and P < 0.05, respectively). The cathepsin D level had prognostic value in patients with node-positive disease (P = 0.001) and appeared to be particularly useful in association with the progesterone receptor status by isolating a high-risk subgroup of patients (high cathepsin D level; negative progesterone receptor status). CONCLUSIONS This first prospective study confirmed the prognostic value of the cathepsin D level in association with other major prognostic factors. The next step will be to determine whether the subset of patients with high cathepsin D levels would benefit from adjuvant therapy. |
| تدمد: | 1097-0142 0008-543X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43446c0b15966570dc6b2c2a8dacec3c https://doi.org/10.1002/1097-0142(19930315)71:6<2006::aid-cncr2820710614>3.0.co;2-q |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....43446c0b15966570dc6b2c2a8dacec3c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
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