A liquid biopsy signature predicts lymph node metastases in T1 oesophageal squamous cell carcinoma: implications for precision treatment strategy
| العنوان: | A liquid biopsy signature predicts lymph node metastases in T1 oesophageal squamous cell carcinoma: implications for precision treatment strategy |
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| المؤلفون: | Liyan Xue, Zitong Zhao, Minjie Wang, Liying Ma, Hua Lin, Shaoming Wang, Xuemin Xue, Linxiu Liu, Bingzhi Wang, Zhuo Li, Zhaoyang Yang, Ning Lu, Qimin Zhan, Yongmei Song |
| المصدر: | British Journal of Cancer. 127:2052-2059 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | MicroRNAs, Cancer Research, Esophageal Neoplasms, Oncology, Lymphatic Metastasis, Liquid Biopsy, Humans, Esophageal Squamous Cell Carcinoma |
| الوصف: | The treatment strategies for T1 oesophageal squamous cell carcinoma (ESCC) patients with or without lymph node metastasis (LNM) are different. Given the advantages of the minimally invasive, sensitive and real-time detection, liquid biopsy has become an important cancer diagnostic and prognostic tool.MiRNA array and small-RNA sequencing were performed. Then, 222 formalin-fixed and paraffin-embedded tumour samples and 229 pretreatment serum samples from T1 ESCC patients were used to verify and evaluate the results.We demonstrated that serum miR-20b-5p could predict LNM in T1 ESCC patients. The AUC for serum miR-20b-5p was higher (0.827) than those for lymphovascular invasion (LVI) (0.751, P = 0.2128), invasion depth (0.662, P = 0.0027) and tumour differentiation grade (0.634, P = 0.0019). A nomogram for predicting LNM with three independent significant predictors (miR-20b-5p, LVI and invasion depth) was constructed with a concordance index of 0.931. Serum miR-20b-5p was also significantly correlated with disease-free survival (P 0.001). An algorithm of improved T1 ESCC treatment strategy after biopsy and/or after endoscopic resection based on serum miR-20b-5p level was constructed.This study suggests that serum miR-20b-5p is a potential biomarker for predicting LNM and can be helpful for precise clinical decision-making strategies and improve treatment outcomes for T1 ESCC patients. |
| تدمد: | 1532-1827 0007-0920 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437c5fbdb3e4462ca9c091511109d77b https://doi.org/10.1038/s41416-022-01997-y |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....437c5fbdb3e4462ca9c091511109d77b |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15321827 00070920 |
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