أعرض في EDS

Type and timing of menopausal hormone therapy and breast cancer risk: individual participant meta-analysis of the worldwide epidemiological evidence

التفاصيل البيبلوغرافية
العنوان: Type and timing of menopausal hormone therapy and breast cancer risk: individual participant meta-analysis of the worldwide epidemiological evidence
المؤلفون: N Hamajima, K Hirose, K Tajima, T Rohan, CM Friedenreich, SM Gapstur, MM Gaudet, RJ Coates, JM Liff, E Kakouri, Y Marcou, SW Duffy, A Morabia, L Schuman, W Stewart, M Szklo, P Band, AJ Coldman, RP Gallagher, TG Hislop, P Yang, SR Cummings, J Hu, KC Johnson, Y Mao, P Chao, J Lissowska, K Canfell, PL Horn-Ross, LM Kolonel, AMY Nomura, T Bishop, D Palli, S De Sanjose, CA Gonzalez, N Lee, P Marchbanks, HW Ory, HB Peterson, P Wingo, K Ebeling, D Kunde, P Nishan, L Bergkvist, JL Hopper, F Sitas, S Franceschi, L Dal Maso, TH Chan, AH Eliassen, RM Tamimi, WC Willett, V Gajalakshmi, N Martin, T Pardthaisong, S Silpisornkosol, C Theetranont, B Boosiri, S Chutivongse, P Jimakorn, P Virutamasen, C Wongsrichanalai, A Neugut, R Santella, A Hadjisavvas, K Kyriacou, M Loizidou, CJ Baines, N Kreiger, AB Miller, C Wall, A Tjonneland T Jorgensen, C Stahlberg, A T0nnes Pedersen, E Negri, SE Hankinson, D Flesch-Janys, C La Vecchia, N Hakansson, I Heuch, HO Adami, E Weiderpass, A Ekbom, G Erlandsson, I Persson, C Magnusson, L Jones, K McPherson, A Neil, M Vessey, D Yeates, G Berry, J Cooper Booth, T Jelihovsky, R MacLennan, J Chang-Claude, R Kaaks, M Iwasaki, S Tsugane, GL Anderson, JR Daling, WB Hutchinson, CI Li, KE Malone, M Mandelson, PA Newcomb, EA Noonan, RM Ray, JL Stanford, MTC Tang, DB Thomas, NS Weiss, E White, A Izquierdo, P Viladiu, KM Egan, HR Cuevas, P Ontiveros, A Palet, SB Salazar, N Aristizabal, A Cuadros, L Tryggvadottir, EJ Olafsdottir, E Riboli, N Andrieu, A Bachelot, A Bremond, B Gairard, J Lansac, MG Le, L Piana, R Renaud, MC Boutron-Ruault, N Chabbert-Buffet, F Clavel-Chapelon, A Fournier, S Mesrine, F Levi, M Jones, AJ Swerdlow, A Wolk, K Kosmelj, M Primic-Zakelj, J Stare, G Torres-Mejia, I Romieu, P Boyle, F Lubin, B Modan, E Ron, Y Wax, M Ferraroni, E Marubini, EM Monninkhof, NC Onland-Moret, PHM Peeters, GD Friedman, RA Hiatt, M Touillaud, WL Beeson, G Fraser, J Peto, RL Hanson, MC Leske, MC Mahoney, PC Nasca, AO Varma, AL Weinstein, RA Goldbohm, PA van den Brandt, N Chantarakul, S Koetsawang, D Rachawat, MC Pike, M Gerber, S Richardson, C Segala, S Teitelbaum, D Gatei, P Kenya, A Kungu, JG Mati, LA Brinton, M Freedman, R Hoover, C Schairer, RG Ziegler, E Banks, R Spirtas, HP Lee, MA Rookus, FE van Leeuwen, JA Schoenberg, S Graff-Iversen, R Selmer, S Atkinson, I Barnes, V Beral, D Bull, T Gathani, A Goodill, J Green, C Hermon, T Key, K Pirie, G Reeves, K Shaw, TO Yang, R Collins, HC Pan, R Peto, R Ghiasvand, K Mabuchi, D Preston, SE McCann, P Hannaford, C Kay, JM Hampton, LJ Titus, A Trentham-Dietz, B Liu, YT Gao, F Jin, J-M Yuan, HY Wei, T Yun, C Zhiheng, PF Coogan, JR Palmer, L Rosenberg, EM John, Q-S Wang, M Kawai, Y Minami, I Tsuji, M Kumle, H Stalsberg, E Lund, EO Fourkala, I Jacobs, U Menon, A Ryan, L Hartman, H Olsson, K Katsouyanni, A Trichopoulou, A Tzonou, KA Baltzell, A Dabancens, L Martinez, R Molina, O Salas, L Rosero-Bixby, FE Alexander, K Anderson, AR Folsom, MD Gammon, BS Hulka, R Millikan, CED Chilvers, M McCredie, C Paul, DCG Skegg, GFS Spears, F Lumachi, TR Rebbeck, RA Apelo, J Baens, JR de la Cruz, B Javier, LB Lacaya, CA Ngelangel, J Cauley, for the Study of Osteoporotic Fractures, C Bain, F Schofield, V Siskind, L Bernstein, S Enger, RW Haile, A Paganini-Hill, G Ursin, AH Wu, MC Yu, M Ewertz, EA Clarke, XO Shu, W Zheng, M Gass, MJ O’Sullivan, A Kalache, TMM Farley, S Holck, O Meirik, A Fukao, X Zhou
المساهمون: RS: GROW - R1 - Prevention, RS: CAPHRI - R5 - Optimising Patient Care, Epidemiologie, N Hamajima, K Hirose, K Tajima, T Rohan, CM Friedenreich, SM Gapstur, MM Gaudet, RJ Coate, JM Liff, E Kakouri, Y Marcou, SW Duffy, A Morabia, L Schuman, W Stewart, M Szklo, P Band, AJ Coldman, RP Gallagher, TG Hislop, P Yang, SR Cumming, J Hu, KC Johnson, Y Mao, P Chao, J Lissowska, K Canfell, PL Horn-Ro, LM Kolonel, AMY Nomura, T Bishop, D Palli, S De Sanjose, CA Gonzalez, N Lee, P Marchbank, HW Ory, HB Peterson, P Wingo, K Ebeling, D Kunde, P Nishan, L Bergkvist, JL Hopper, F Sita, S Franceschi, L Dal Maso, TH Chan, AH Eliassen, RM Tamimi, WC Willett, V Gajalakshmi, N Martin, T Pardthaisong, S Silpisornkosol, C Theetranont, B Boosiri, S Chutivongse, P Jimakorn, P Virutamasen, C Wongsrichanalai, A Neugut, R Santella, A Hadjisavva, K Kyriacou, M Loizidou, CJ Baine, N Kreiger, AB Miller, C Wall, A Tjonneland T Jorgensen, C Stahlberg, A T0nnes Pedersen, E Negri, SE Hankinson, D Flesch-Jany, C La Vecchia, N Hakansson, I Heuch, HO Adami, E Weiderpa, A Ekbom, G Erlandsson, I Persson, C Magnusson, L Jone, K McPherson, A Neil, M Vessey, D Yeate, G Berry, J Cooper Booth, T Jelihovsky, R MacLennan, J Chang-Claude, R Kaak, M Iwasaki, S Tsugane, GL Anderson, JR Daling, WB Hutchinson, CI Li, KE Malone, M Mandelson, PA Newcomb, EA Noonan, RM Ray, JL Stanford, MTC Tang, DB Thoma, NS Wei, E White, A Izquierdo, P Viladiu, KM Egan, HR Cueva, P Ontivero, A Palet, SB Salazar, N Aristizabal, A Cuadro, L Tryggvadottir, EJ Olafsdottir, E Riboli, N Andrieu, A Bachelot, A Bremond, B Gairard, J Lansac, MG Le, L Piana, R Renaud, MC Boutron-Ruault, N Chabbert-Buffet, F Clavel-Chapelon, A Fournier, S Mesrine, F Levi, M Jone, AJ Swerdlow, A Wolk, K Kosmelj, M Primic-Zakelj, J Stare, G Torres-Mejia, I Romieu, P Boyle, F Lubin, B Modan, E Ron, Y Wax, M Ferraroni, E Marubini, EM Monninkhof, NC Onland-Moret, PHM Peeter, GD Friedman, RA Hiatt, M Touillaud, WL Beeson, G Fraser, J Peto, RL Hanson, MC Leske, MC Mahoney, PC Nasca, AO Varma, AL Weinstein, RA Goldbohm, PA van den Brandt, N Chantarakul, S Koetsawang, D Rachawat, MC Pike, M Gerber, S Richardson, C Segala, S Teitelbaum, D Gatei, P Kenya, A Kungu, JG Mati, LA Brinton, M Freedman, R Hoover, C Schairer, RG Ziegler, E Bank, R Spirta, HP Lee, MA Rooku, FE van Leeuwen, JA Schoenberg, S Graff-Iversen, R Selmer, S Atkinson, I Barne, V Beral, D Bull, T Gathani, A Goodill, J Green, C Hermon, T Key, K Pirie, G Reeve, K Shaw, TO Yang, R Collin, HC Pan, R Peto, R Ghiasvand, K Mabuchi, D Preston, SE McCann, P Hannaford, C Kay, JM Hampton, LJ Titu, A Trentham-Dietz, B Liu, YT Gao, F Jin, J-M Yuan, HY Wei, T Yun, C Zhiheng, PF Coogan, JR Palmer, L Rosenberg, EM John, Q-S Wang, M Kawai, Y Minami, I Tsuji, M Kumle, H Stalsberg, E Lund, EO Fourkala, I Jacob, U Menon, A Ryan, L Hartman, H Olsson, K Katsouyanni, A Trichopoulou, A Tzonou, KA Baltzell, A Dabancen, L Martinez, R Molina, O Sala, L Rosero-Bixby, FE Alexander, K Anderson, AR Folsom, MD Gammon, BS Hulka, R Millikan, CED Chilver, M McCredie, C Paul, DCG Skegg, GFS Spear, F Lumachi, TR Rebbeck, RA Apelo, J Baen, JR de la Cruz, B Javier, LB Lacaya, CA Ngelangel, J Cauley, for the Study of Osteoporotic Fracture, C Bain, F Schofield, V Siskind, L Bernstein, S Enger, RW Haile, A Paganini-Hill, G Ursin, AH Wu, MC Yu, M Ewertz, EA Clarke, XO Shu, W Zheng, M Ga, MJ O’Sullivan, A Kalache, TMM Farley, S Holck, O Meirik, A Fukao, X Zhou, Pirie, K, Cancer, Collaborative Group on Hormonal Factors in Breast
المصدر: Lancet, 394(10204), 1159-1168. Elsevier Science
سنة النشر: 2019
مصطلحات موضوعية: Adult, Risk, Oncology, medicine.medical_specialty, Time Factors, menopause, Breast Neoplasms, 030204 cardiovascular system & hematology, meta-analysi, 03 medical and health sciences, breast cancer, 0302 clinical medicine, Breast cancer, ESTROGEN-PLUS-PROGESTIN, Risk Factors, Internal medicine, Epidemiology of cancer, Epidemiology, medicine, Humans, Obesity, 030212 general & internal medicine, Progesterone, Aged, Principal Component Analysis, INITIATIVE CLINICAL-TRIAL, hormone therapy, business.industry, Estrogen Replacement Therapy, Estrogens, General Medicine, Middle Aged, medicine.disease, 3. Good health, Logistic Models, POSTMENOPAUSAL WOMEN, Meta-analysis, epidemiology, Drug Therapy, Combination, Female, Menopausal hormone therapy, Progestins, business
الوصف: Background: Published findings on breast cancer risk associated with different types of menopausal hormone therapy (MHT) are inconsistent, with limited information on long-term effects. We bring together the epidemiological evidence, published and unpublished, on these associations, and review the relevant randomised evidence. Methods: Principal analyses used individual participant data from all eligible prospective studies that had sought information on the type and timing of MHT use; the main analyses are of individuals with complete information on this. Studies were identified by searching many formal and informal sources regularly from Jan 1, 1992, to Jan 1, 2018. Current users were included up to 5 years (mean 1·4 years) after last-reported MHT use. Logistic regression yielded adjusted risk ratios (RRs) comparing particular groups of MHT users versus never users. Findings: During prospective follow-up, 108 647 postmenopausal women developed breast cancer at mean age 65 years (SD 7); 55 575 (51%) had used MHT. Among women with complete information, mean MHT duration was 10 years (SD 6) in current users and 7 years (SD 6) in past users, and mean age was 50 years (SD 5) at menopause and 50 years (SD 6) at starting MHT. Every MHT type, except vaginal oestrogens, was associated with excess breast cancer risks, which increased steadily with duration of use and were greater for oestrogen-progestagen than oestrogen-only preparations. Among current users, these excess risks were definite even during years 1–4 (oestrogen-progestagen RR 1·60, 95% CI 1·52–1·69; oestrogen-only RR 1·17, 1·10–1·26), and were twice as great during years 5–14 (oestrogen-progestagen RR 2·08, 2·02–2·15; oestrogen-only RR 1·33, 1·28–1·37). The oestrogen-progestagen risks during years 5–14 were greater with daily than with less frequent progestagen use (RR 2·30, 2·21–2·40 vs 1·93, 1·84–2·01; heterogeneity p Interpretation: If these associations are largely causal, then for women of average weight in developed countries, 5 years of MHT, starting at age 50 years, would increase breast cancer incidence at ages 50–69 years by about one in every 50 users of oestrogen plus daily progestagen preparations; one in every 70 users of oestrogen plus intermittent progestagen preparations; and one in every 200 users of oestrogen-only preparations. The corresponding excesses from 10 years of MHT would be about twice as great.
اللغة: English
تدمد: 0140-6736
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::439d0f8027a6f9d2226fb0e42b5966f1
https://cris.maastrichtuniversity.nl/en/publications/88a75911-ca7a-43e6-91a1-ba6c24758e34
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....439d0f8027a6f9d2226fb0e42b5966f1
قاعدة البيانات: OpenAIRE
الوصف
تدمد:01406736