Functional disorder of primary immunity responding to respiratory syncytial virus infection in offspring mice exposed to a flame retardant, decabrominated diphenyl ether, perinatally
| العنوان: | Functional disorder of primary immunity responding to respiratory syncytial virus infection in offspring mice exposed to a flame retardant, decabrominated diphenyl ether, perinatally |
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| المؤلفون: | Katsuhiko Konno, Rie Sawamura, Tomomi Shimizu, Wataru Watanabe, Masahiko Kurokawa, Akane Hino |
| المصدر: | Journal of Medical Virology. 82:1075-1082 |
| بيانات النشر: | Wiley, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Lipopolysaccharide, Offspring, Respiratory Syncytial Virus Infections, Biology, Virus, Mice, chemistry.chemical_compound, Organ Culture Techniques, Immune system, Immunity, Virology, medicine, Animals, Immunologic Factors, Respiratory system, Lung, Flame Retardants, Mice, Inbred BALB C, Perinatal Exposure, medicine.diagnostic_test, Phenyl Ethers, respiratory system, Immunity, Innate, Respiratory Syncytial Viruses, Infectious Diseases, Bronchoalveolar lavage, chemistry, Immunology, Cytokines, Female, Bronchoalveolar Lavage Fluid |
| الوصف: | Perinatal exposure to a representative flame retardant, decabrominated diphenyl ether (DBDE), was shown previously to increase viral titers in the lungs of respiratory syncytial virus (RSV)-infected offspring on day 5 post-infection, resulting in exacerbation of pneumonia. In this study, the significant increase of pulmonary viral titers was confirmed even on day 1 post-infection and the effect on the primary immune response to RSV infection were examined to assess a mode of DBDE action on developmental immunotoxicity. On day 1 after infection, the secretion of both TNF-alpha and IL-6 decreased significantly in the bronchoalveolar lavage fluid prepared from RSV-infected offspring exposed to DBDE perinatally, but IL-1beta increased. However, in ex vivo lipopolysaccharide stimulation test, the productivity of TNF-alpha in the bronchoalveolar lavage cells, which are mainly primary immune cells responding to RSV infection, prepared from offspring mice exposed to DBDE perinatally was not lower than that in the control. The primary immune cells retained normally the ability of cytokine production after the DBDE exposure. Gene expressions of innate pattern recognition receptors (Toll-like receptor 3 and 4, melanoma differentiation-associated gene-5, and retinoic acid-inducible gene I) in lung tissues were not affected by DBDE exposure. Because the levels of TNF-alpha, IL-6, and IL-1beta are known to be elevated in the lungs of RSV-infected mice, these irregular productions due to perinatal DBDE exposure indicate a disorder of the primary immune response to RSV infection. Thus, perinatal exposure to DBDE was suggested to cause a functional disorder of primary immunity responding to RSV infection. |
| تدمد: | 1096-9071 0146-6615 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b228672b08e6c0155be2c18bc057e2 https://doi.org/10.1002/jmv.21770 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....43b228672b08e6c0155be2c18bc057e2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10969071 01466615 |
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