Effects of 2(3)-Tert-Butyl-4-Hydroxyanisole Pretreatment on Cefpiramide Binding to Mouse Glutathione S-Transferases
| العنوان: | Effects of 2(3)-Tert-Butyl-4-Hydroxyanisole Pretreatment on Cefpiramide Binding to Mouse Glutathione S-Transferases |
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| المؤلفون: | Masumi Baba, Norio Nozue, Toshiaki Haga, Hajime Nishiya, Otohiko Kunii, Yuichirou Ueda, Yasuo Ono, Takashi Komatsu |
| المصدر: | Pharmacology. 39:213-223 |
| بيانات النشر: | S. Karger AG, 1989. |
| سنة النشر: | 1989 |
| مصطلحات موضوعية: | Indocyanine Green, Ratón, Butylated Hydroxyanisole, Cefoperazone, Cefpiramide, Plasma protein binding, Excretion, Mice, chemistry.chemical_compound, Cytosol, medicine, Animals, Polyacrylamide gel electrophoresis, Glutathione Transferase, Pharmacology, General Medicine, Glutathione, Antimicrobial, In vitro, Cephalosporins, Diet, Kinetics, Liver, chemistry, Biochemistry, Electrophoresis, Polyacrylamide Gel, Female, Protein Binding, medicine.drug |
| الوصف: | Binding of cefpiramide (CPM) and other beta-lactam antimicrobial agents to 2(3)-tert-butyl-4-hydroxyanisole (BHA)-induced liver glutathione (GSH) S-transferases (EC 2.5.1.18) from CD-1 mice was studied. A marked induction of hepatic GSH S-transferase from mice fed BHA was observed. Gel chromatography of liver cytosol from mice fed BHA showed an increased binding of CPM, cefotetan and cefazolin to BHA-induced GSH S-transferases. The extent of their binding to GSH S-transferase seemed to be correlated with the extent of their excretion into the bile. Binding of CPM to the GSH S-transferase fraction was inhibited by both indocyanine green, which is known to bind liver GSH S-transferases intensively, and by cefoperazon, which is mainly excreted into the bile. This study suggests that GSH S-transferases are the main binding proteins of CPM in the liver cytosol fraction and play an important role as carrier proteins of CPM and some antimicrobial agents in mouse liver. |
| تدمد: | 1423-0313 0031-7012 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b4f1d40b828c78394edf6adbc00033 https://doi.org/10.1159/000138600 |
| رقم الأكسشن: | edsair.doi.dedup.....43b4f1d40b828c78394edf6adbc00033 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230313 00317012 |
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