Endothelin-1 gene and endothelin receptor A gene polymorphisms in severe pulmonary hypertension associated with rheumatic mitral valve disease
| العنوان: | Endothelin-1 gene and endothelin receptor A gene polymorphisms in severe pulmonary hypertension associated with rheumatic mitral valve disease |
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| المؤلفون: | Pratishtha Mehra, Vimal Mehta, Jamal Yusuf, Rishi Sukhija, Wilbert Aronow |
| المصدر: | Archives of Medical Science. 18:260-266 |
| بيانات النشر: | Termedia Sp. z.o.o., 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | General Medicine |
| الوصف: | IntroductionEndothelin-1 (ET-1) gene polymorphisms are implicated in pathogenesis of idiopathic pulmonary arterial hypertensionMaterial and methodsWe studied ET-1 (Lys198Asn and 3A/4A) and endothelin receptor A (ETA) gene (His323His) polymorphisms in 123 subjects with pulmonary hypertension associated with rheumatic mitral valve disease (PH-MVD) and 123 healthy controls.ResultsThe mutant homozygous Asn/Asn genotype in Lys198Asn and T/T genotype in His323His polymorphism was more prevalent in PH-MVD group. Presence of Asn/Asn genotype was significantly associated with increased risk (odds ratio 3.9).ConclusionsET-1 and ETA gene polymorphisms are prevalent in PH-MVD group suggesting that they may predispose to the development of PH. |
| تدمد: | 1896-9151 1734-1922 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b6eeb41f4f975db24d0dfa41c00f50 https://doi.org/10.5114/aoms/144630 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....43b6eeb41f4f975db24d0dfa41c00f50 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18969151 17341922 |
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