Absent immune response to SARS-CoV-2 in a 3-month recurrence of coronavirus disease 2019 (COVID-19) case
| العنوان: | Absent immune response to SARS-CoV-2 in a 3-month recurrence of coronavirus disease 2019 (COVID-19) case |
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| المؤلفون: | Lingyan Fan, Qiaoyun Shi, Qifa Song, Zuoan Huang, Shuyuan Ye, Yedan Sun, Guosheng Gao, Zhe Zhu |
| المصدر: | Infection |
| بيانات النشر: | Springer Berlin Heidelberg, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Disease, Long-term viral shedding, Gastroenterology, 0302 clinical medicine, COVID-19 Testing, Recurrence, Medicine, 030212 general & internal medicine, Reverse Transcriptase Polymerase Chain Reaction, Novel coronavirus (SARS-CoV-2), General Medicine, Viral Load, Interleukin-10, Virus Shedding, Hospitalization, Elevated serum creatinine, Infectious Diseases, C-Reactive Protein, Creatinine, Tumor necrosis factor alpha, Viral load, Microbiology (medical), medicine.medical_specialty, Fever, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 030106 microbiology, Antiviral Agents, Virus, 03 medical and health sciences, Interferon-gamma, Immune system, Internal medicine, Lymphopenia, Humans, Viral shedding, Immune response, Aged, Original Paper, business.industry, Interleukin-6, SARS-CoV-2, Tumor Necrosis Factor-alpha, Immunity, COVID-19, Coronavirus disease 2019 (COVID-19), Interleukin-2, business, Tomography, X-Ray Computed, Biomarkers |
| الوصف: | Background The viral persistence in patients with Coronavirus Disease 2019 (COVID-19) remains to be investigated. Methods We investigated the viral loads, therapies, clinical features, and immune responses in a 70-year patient tested positive for SARS-CoV-2 for 3 months. Findings The patient exhibited the highest prevalence of abnormal indices of clinical features and immune responses at the first admission, including fever (38.3 ℃), decreased lymphocytes (0.83 × 109/L) and serum potassium (3.1 mmol/L), as well as elevated serum creatinine (115 µmol/L), urea (8.6 mmol/L), and C-reactive protein (80 mg/L). By contrast, at the second and the third admission, these indices were all normal. Through three admissions, IL-2 increased from 0.14 pg/mL, 0.69 pg/mL, to 0.91 pg/mL, while IL-6 decreased from 11.78 pg/mL, 1.52 pg/mL, to 0.69 pg/mL, so did IL-10 from 5.13 pg/mL, 1.85 pg/mL, to 1.75 pg/mL. The steady declining trend was also found in TNF-α (1.49, 1.15, and 0.85 pg/mL) and IFN-γ (0.64, 0.42, and 0.27 pg/mL). The threshold cycle values of RT-PCR were 26.1, 30.5, and 23.5 for ORFlab gene, and 26.2, 30.6, and 22.7 for N gene, showing the patient had higher viral loads at the first and the third admission than during the middle term of the disease. The patient also showed substantially improved acute exudative lesions on the chest CT scanning images. Conclusions The patient displayed declining immune responses in spite of the viral shedding for 3 months. We inferred the declining immune responses might result from the segregation of the virus from the immune system. |
| اللغة: | English |
| تدمد: | 1439-0973 0300-8126 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d8a1b1c63fd65cc4481600d86c1072 http://europepmc.org/articles/PMC7386381 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....43d8a1b1c63fd65cc4481600d86c1072 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14390973 03008126 |
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