Serial changes in cardiac sympathetic nervous function after transcatheter aortic valve replacement: A prospective observational study using 123I-meta-iodobenzylguanidine imaging
| العنوان: | Serial changes in cardiac sympathetic nervous function after transcatheter aortic valve replacement: A prospective observational study using 123I-meta-iodobenzylguanidine imaging |
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| المؤلفون: | Shunsuke Nakamura, Masaki Yashige, Kan Zen, Takeshi Nakamura, Michiyo Yamano, Nagara Tamaki, Satoaki Matoba, Satoshi Numata, Kazuaki Takamatsu, Tetsuhiro Yamano, Yoshito Kadoya, Nobuyasu Ito, Tomotaka Fujimoto, Hitoshi Yaku, Hidetake Kawajiri |
| المصدر: | Journal of Nuclear Cardiology. 29:2652-2663 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Aortic valve, medicine.medical_specialty, Transcatheter aortic, business.industry, medicine.medical_treatment, Meta iodobenzylguanidine, Hemodynamics, medicine.disease, Stenosis, medicine.anatomical_structure, Valve replacement, Internal medicine, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, Observational study, Washout rate, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Purpose:Transcatheter aortic valve replacement (TAVR) can rapidly improve cardiac sympathetic nervous function (CSNF) within 2 weeks in patients with aortic stenosis (AS). However, it remains unclear whether such short-term improvements will be sustained thereafter. The present study aimed to investigate the mid-term (i.e., 6–12 months) effects of TAVR on CSNF in patients with severe AS using 123I-meta-iodobenzylguanidine (MIBG) imaging.Methods:Patients with severe AS who were scheduled to undergo TAVR between October 2017 and June 2019 were enrolled in this single-centre, prospective, observational study. MIBG imaging was performed at baseline, within 2 weeks after TAVR, and at 6–12 months post-TAVR to evaluate the heart–mediastinum ratio (H/M) and washout rate (WR). Differences between each MIBG parameter at three time points were analysed, and factors involved in the long-term improvement in the late H/M were investigated. Results:Of 183 consecutive patients, 75 (19 men; median age: 86 years) were evaluated. The late H/M significantly improved within 2 weeks after TAVR (P=0.041) and further improved over 6–12 months after TAVR (P=0.041). The WR rapidly improved immediately after TAVR (P=0.003) but remained unchanged at 6–12 months (P=0.827). Multivariate analysis revealed that the baseline mean aortic valve pressure gradient (mPG) was an independent predictor of mid-term improvement in the late H/M (>0.1) (adjusted odds ratio: 0.035; 95% confidence interval: 0.004–0.070; P=0.037). Patients with a high baseline mPG (≥58 mmHg) exhibited a significantly greater increase in the late H/M than those with a low baseline mPG (P=0.029).Conclusions:CSNF, as denoted by the late H/M, demonstrated sustained improvement from within 2 weeks after TAVR until 6–12 months later. Such improvement was related to baseline hemodynamic AS severity. |
| تدمد: | 1532-6551 1071-3581 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fad1e8155cb0642ba6a2cd9aeb75d9 https://doi.org/10.1007/s12350-021-02799-0 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....43fad1e8155cb0642ba6a2cd9aeb75d9 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15326551 10713581 |
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