Temporal Dynamic Changes of Intrinsic Brain Activity Associated with Cognitive Reserve in Prodromal Alzheimer's Disease

التفاصيل البيبلوغرافية
العنوان: Temporal Dynamic Changes of Intrinsic Brain Activity Associated with Cognitive Reserve in Prodromal Alzheimer's Disease
المؤلفون: Qingze Zeng, Guoping Peng, Mengjie Hu, Yajie Lin, Benyan Luo
المصدر: Journal of Alzheimer's disease : JAD. 81(3)
سنة النشر: 2021
مصطلحات موضوعية: Male, medicine.medical_specialty, Intrinsic activity, Brain activity and meditation, Prodromal Symptoms, Neuroimaging, 050105 experimental psychology, 03 medical and health sciences, 0302 clinical medicine, Cognitive Reserve, Alzheimer Disease, Internal medicine, medicine, Humans, 0501 psychology and cognitive sciences, Cognitive Dysfunction, Cognitive reserve, Aged, Fluorodeoxyglucose, Aged, 80 and over, medicine.diagnostic_test, business.industry, General Neuroscience, 05 social sciences, Brain, Cognition, General Medicine, Middle Aged, Magnetic Resonance Imaging, Psychiatry and Mental health, Clinical Psychology, Positron-Emission Tomography, Cardiology, Female, Analysis of variance, Geriatrics and Gerontology, business, Functional magnetic resonance imaging, 030217 neurology & neurosurgery, medicine.drug
الوصف: Background: Cognitive reserve (CR) is an important protective factor for Alzheimer’s disease (AD), yet its mechanism has not been fully elucidated. Objective: To explore the effect of CR on resting and dynamic brain intrinsic activity in patients with mild cognitive impairment (MCI). Methods: 65 amyloid-β PET-negative (Aβ-) normal controls (NC) and 30 amyloid-β PET-positive (Aβ+) MCI patients underwent resting-state functional magnetic resonance imaging were included from Alzheimer’s Disease Neuroimaging Initiative. According to the years of education, the subjects were divided into high education group and low education group. A two-way analysis of variance was employed for the fractional amplitude of low-frequency fluctuation (fALFF) and dynamic fALFF (dfALFF) comparisons among the four groups. Moreover, the interaction effect of neuroimaging×pathology on clinical cognitive function was tested with linear regression analysis. Results: The value of fALFF in the left prefrontal lobe was increased in Aβ+ MCI patients compared to Aβ- NC. The significant interactive effect between disease state and education (binary factor) was observed in the right parahippocampal gyrus (PHG) for fALFF, the right PHG and the right inferior parietal lobule for dfALFF. While no significant results between education (continuous factor) and brain activity was found in voxel-by-voxel analysis. For MCI patients, a significant fluorodeoxyglucose hypometabolic convergence index×right PHG dfALFF interaction was found, indicating the maintenance of executive function at higher levels of dfALFF in the right PHG. Conclusion: High CR can alleviate the impairment of hypometabolism on executive function in MCI patients, which is partially achieved by regulating the dynamic brain activity in the right PHG.
تدمد: 1875-8908
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ff7f5e80218f5815bf804f627ee95d
https://pubmed.ncbi.nlm.nih.gov/33935072
رقم الأكسشن: edsair.doi.dedup.....43ff7f5e80218f5815bf804f627ee95d
قاعدة البيانات: OpenAIRE