Shrimp Allergy in Italian Adults: A Multicenter Study Showing a High Prevalence of Sensitivity to Novel High Molecular Weight Allergens
| العنوان: | Shrimp Allergy in Italian Adults: A Multicenter Study Showing a High Prevalence of Sensitivity to Novel High Molecular Weight Allergens |
|---|---|
| المؤلفون: | F. Nebiolo, Giselda Colombo, R Asero, M.E. Conte, Ariano R, F Murzilli, Gianni Mistrello, F Emiliani, R. Longo, Gianenrico Senna, F. Lodi Rizzini, F. Della Torre, P. Minale, Donatella Macchia, O Quercia, M De Carli, Danilo Villalta, Mariangiola Crivellaro, Stefano Amato |
| المصدر: | International Archives of Allergy and Immunology. 157:3-10 |
| بيانات النشر: | S. Karger AG, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Allergy, animal structures, Adolescent, Immunology, Prevalence, macromolecular substances, medicine.disease_cause, Cross-reactivity, Arthropod Proteins, Young Adult, Food allergy, Epidemiology, medicine, Animals, Humans, Immunology and Allergy, Child, Aged, Skin Tests, House dust mite, biology, business.industry, fungi, General Medicine, Allergens, Immunoglobulin E, Middle Aged, musculoskeletal system, biology.organism_classification, medicine.disease, Shrimp, Molecular Weight, Multicenter study, Female, business, Food Hypersensitivity |
| الوصف: | Background: Shrimp is a frequent cause of food allergy worldwide. Besides tropomyosin, several allergens have been described recently. Objective: We investigated which allergens are involved in Italian shrimp-allergic adults. Methods: Sera from 116 shrimp-allergic patients selected in 14 Italian allergy centers were studied. Skin prick tests with house dust mite (HDM) as well as measurements of IgE to Pen a 1 (shrimp tropomyosin) and whole shrimp extract were performed. All sera underwent shrimp immunoblot analysis, and inhibition experiments using HDM extract as inhibitor were carried out on some Pen a 1-negative sera. Results: Immunoblots showed much variability. IgE reactivity at about 30 kDa (tropomyosin) was found in 90 kDa was frequent. Further reactivities at 14–18, 25, 43–50, about 60 and about 80 kDa were detected. Most subjects had a history of shrimp-induced systemic symptoms irrespective of the relevant allergen protein. IgE to Pen a 1 were detected in sera from 46 (41%) patients. Skin reactivity to HDM was found in 43/61 (70%) Pen 1-negative subjects and inhibition studies showed that pre-adsorption of sera with HDM extract induced a marked weakening of the signal at >67 kDa. Conclusions: Several allergens other than tropomyosin are involved in shrimp allergy in adult Italian patients. Some hitherto not described high molecular weight allergens seem particularly relevant in this population and their cross-reactivity with HDM allergens makes them novel potential panallergens of invertebrates. |
| تدمد: | 1423-0097 1018-2438 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4406404431b47347243bdcc5a4201276 https://doi.org/10.1159/000324470 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....4406404431b47347243bdcc5a4201276 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230097 10182438 |
|---|