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The association between brain-derived neurotrophic factor Val66Met variants and psychotic symptoms in posttraumatic stress disorder

التفاصيل البيبلوغرافية
العنوان: The association between brain-derived neurotrophic factor Val66Met variants and psychotic symptoms in posttraumatic stress disorder
المؤلفون: Dragica Kozarić-Kovačić, Gordana Nedić, Mirjana Grubišić-Ilić, Matea Nikolac, Martina Blazev, Nela Pivac, Iva Rakoš, Dorotea Muck-Seler
المصدر: The world journal of biological psychiatry
سنة النشر: 2011
مصطلحات موضوعية: Adult, Male, Psychosis, medicine.medical_specialty, Genotype, Croatia, BDNF, polymorphism, PTSD, psychosis, veterans, behavioral disciplines and activities, White People, Stress Disorders, Post-Traumatic, 03 medical and health sciences, 0302 clinical medicine, Neurotrophic factors, Clinical Medical Sciences, mental disorders, medicine, Humans, Genetic Predisposition to Disease, Psychiatry, Association (psychology), Biological Psychiatry, health care economics and organizations, Functional polymorphism, Veterans, Brain-derived neurotrophic factor, Combat Disorders, Polymorphism, Genetic, Brain-Derived Neurotrophic Factor, Case-control study, Middle Aged, medicine.disease, humanities, 030227 psychiatry, Psychiatry and Mental health, Posttraumatic stress, Mood, Psychotic Disorders, Case-Control Studies, Psychology, 030217 neurology & neurosurgery, Clinical psychology
الوصف: Objective: Psychotic symptoms frequently occur in veterans with combat-related posttraumatic stress disorder (PTSD). Brain-derived neurotrophic factor (BDNF) plays a major role in neurodevelopment, neuro-regeneration, neurotransmission, learning, regulation of mood and stress responses. The Met allele of the functional polymorphism, BDNF Val66Met, is associated with psychotic disorders. This study intended to assess whether the Met allele is overrepresented in unrelated Caucasian male veterans with psychotic PTSD compared to veteran controls. Method: The BDNF Val66Met variants were genotyped in 576 veterans: 206 veterans without PTSD and 370 veterans with PTSD subdivided into groups with or without psychotic features. Results: Veterans with psychotic PTSD were more frequently carriers of one or two Met alleles of the BDNF Val66Met polymorphism than veterans with PTSD without psychotic features and veterans without PTSD. Conclusions: The study shows that veterans with psychotic PTSD carried more Met alleles of the BDNF Val66Met than non-psychotic veterans with PTSD or veterans without PTSD. The results might add further support to the hypothesis that psychotic PTSD is a more severe subtype of PTSD.
وصف الملف: application/pdf
تدمد: 1814-1412
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4444e9c277f7a502888b5a25fff41ccf
https://pubmed.ncbi.nlm.nih.gov/21728904
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....4444e9c277f7a502888b5a25fff41ccf
قاعدة البيانات: OpenAIRE
الوصف
تدمد:18141412