GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells
| العنوان: | GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells |
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| المؤلفون: | Tomas Valenta, Konrad Basler, Bahar Degirmenci, Slavica Dimitrieva, George Hausmann |
| المساهمون: | University of Zurich, Valenta, Tomas |
| المصدر: | Nature. 558:449-453 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Colon, Biology, Zinc Finger Protein GLI1, Mice, 03 medical and health sciences, 0302 clinical medicine, GLI1, Intestine, Small, Cell Self Renewal, medicine, Animals, Secretion, Stem Cell Niche, Wnt Signaling Pathway, 1000 Multidisciplinary, Multidisciplinary, Stem Cells, Mesenchymal stem cell, Wnt signaling pathway, Mesenchymal Stem Cells, Intestinal epithelium, 10124 Institute of Molecular Life Sciences, Small intestine, Cell biology, Wnt Proteins, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, biology.protein, 570 Life sciences, biology, Female, Stem cell |
| الوصف: | Wnt-β-catenin signalling plays a pivotal role in the homeostasis of the intestinal epithelium by promoting stem cell renewal1,2. In the small intestine, epithelial Paneth cells secrete Wnt ligands and thus adopt the function of the stem cell niche to maintain epithelial homeostasis3,4. It is unclear which cells comprise the stem cell niche in the colon. Here we show that subepithelial mesenchymal GLI1-expressing cells form this essential niche. Blocking Wnt secretion from GLI1-expressing cells prevents colonic stem cell renewal in mice: the stem cells are lost and, as a consequence, the integrity of the colonic epithelium is corrupted, leading to death. GLI1-expressing cells also play an important role in the maintenance of the small intestine, where they serve as a reserve Wnt source that becomes critical when Wnt secretion from epithelial cells is prevented. Our data suggest a mechanism by which the stem cell niche is adjusted to meet the needs of the intestine via adaptive changes in the number of mesenchymal GLI1-expressing cells. |
| وصف الملف: | s41586-018-0190-3.pdf - application/pdf |
| تدمد: | 1476-4687 0028-0836 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ad01defd0b9d7a2e787e434a88a6c7 https://doi.org/10.1038/s41586-018-0190-3 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....44ad01defd0b9d7a2e787e434a88a6c7 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14764687 00280836 |
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