التفاصيل البيبلوغرافية
العنوان:
2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists
المؤلفون:
George A. Doss , Lex H.T. Van der Ploeg , Qianping Peng , Ravi P. Nargund , Charles Rosenblum , Randall R. Miller , Aurawan Vongs , Palucki Brenda , Tanya MacNeil , Ralph A. Stearns , Min K. Park , David H. Weinberg , Rui Tang , Arthur A. Patchett , Constantin Tamvakopoulos
المصدر:
Bioorganic & Medicinal Chemistry Letters . 15:1993-1996
بيانات النشر:
Elsevier BV, 2005.
سنة النشر:
2005
مصطلحات موضوعية:
Agonist , Stereochemistry , medicine.drug_class , Clinical Biochemistry , Pharmaceutical Science , Carboxamide , Biochemistry , Piperazines , Structure-Activity Relationship , chemistry.chemical_compound , Drug Discovery , medicine , Humans , Receptor , Molecular Biology , biology , Chemistry , Organic Chemistry , biology.organism_classification , In vitro , Piperazine , Microsoma , Microsome , Receptor, Melanocortin, Type 4 , Molecular Medicine , Melanocortin
الوصف:
We report the discovery and optimization of substituted 2-piperazinecarboxamides as potent and selective agonists of the melanocortin subtype-4 receptor. The 5- and 6-alkylated piperazine compounds exhibit low bioactivation potential as measured by covalent binding in microsome preparations.
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e32b60eac4ad2438147bfe723f3834 https://doi.org/10.1016/j.bmcl.2005.02.068
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....44e32b60eac4ad2438147bfe723f3834
قاعدة البيانات:
OpenAIRE
