Cationic surfactants: self-assembly, structure-activity correlation and their biological applications
| العنوان: | Cationic surfactants: self-assembly, structure-activity correlation and their biological applications |
|---|---|
| المؤلفون: | Lucia Ya. Zakharova, Tatiana N. Pashirova, Slavomira Doktorovova, Eliana B. Souto, Ana R. Fernandes, Selma B. Souto, Amélia M. Silva, Elena Sánchez-López |
| المساهمون: | Universidade do Minho |
| المصدر: | Dipòsit Digital de la UB Universidad de Barcelona Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP International Journal of Molecular Sciences, Vol 20, Iss 22, p 5534 (2019) International Journal of Molecular Sciences |
| بيانات النشر: | MDPI, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Green chemistry, Solubilitat dels medicaments, 02 engineering and technology, Review, Surface active agents, 01 natural sciences, lcsh:Chemistry, drug delivery systems, QSAR (Bioquímica), Biotecnologia Industrial [Engenharia e Tecnologia], Moiety, lcsh:QH301-705.5, Spectroscopy, Chemistry, General Medicine, Self-assembly, 021001 nanoscience & nanotechnology, 3. Good health, Computer Science Applications, Drug delivery systems, Sistemes d'alliberament de medicaments, Drug delivery, 0210 nano-technology, Hydrophobic and Hydrophilic Interactions, Farmacologia, Agents tensioactius, Engenharia e Tecnologia::Biotecnologia Industrial, Supramolecular chemistry, 010402 general chemistry, Catalysis, Inorganic Chemistry, QSAR (Biochemistry, Structure-Activity Relationship, Surface-Active Agents, Cations, Amphiphile, 1,4-diazabicyclo[2.2.2]octane, Solubilization, Physical and Theoretical Chemistry, Cationic surfactants, Molecular Biology, Pharmacology, Drug solubility, Nanoestructures, Science & Technology, Organic Chemistry, Cationic polymerization, Chemical modification, Combinatorial chemistry, 0104 chemical sciences, Nanostructures, lcsh:Biology (General), lcsh:QD1-999, Nanocarriers, Antimicrobial nanocarriers |
| الوصف: | The development of biotechnological protocols based on cationic surfactants is a modern trend focusing on the fabrication of antimicrobial and bioimaging agents, supramolecular catalysts, stabilizers of nanoparticles, and especially drug and gene nanocarriers. The main emphasis given to the design of novel ecologically friendly and biocompatible cationic surfactants makes it possible to avoid the drawbacks of nanoformulations preventing their entry to clinical trials. To solve the problem of toxicity various ways are proposed, including the use of mixed composition with nontoxic nonionic surfactants and/or hydrotropic agents, design of amphiphilic compounds bearing natural or cleavable fragments. Essential advantages of cationic surfactants are the structural diversity of their head groups allowing of chemical modification and introduction of desirable moiety to answer the green chemistry criteria. The latter can be exemplified by the design of novel families of ecological friendly cleavable surfactants, with improved biodegradability, amphiphiles with natural fragments, and geminis with low aggregation threshold. Importantly, the development of amphiphilic nanocarriers for drug delivery allows understanding the correlation between the chemical structure of surfactants, their aggregation behavior, and their functional activity. This review focuses on several aspects related to the synthesis of innovative cationic surfactants and their broad biological applications including antimicrobial activity, solubilization of hydrophobic drugs, complexation with DNA, and catalytic effect toward important biochemical reaction. Russian Science Foundation; grant No. 19-73-30012, and from the Portuguese Science and Technology Foundation (FCT) no. SFRH/BPD/101650/2014 granted to SD, SFRH/BD/130555/2017 granted to ARF, and project reference M-ERA-NET/0004/2015 (PAIRED) info:eu-repo/semantics/publishedVersion |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4500cadc5d5f3977bc4d5836b08d378e https://hdl.handle.net/1822/61960 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4500cadc5d5f3977bc4d5836b08d378e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |