Allelic exclusion in transgenic mice carrying mutant human IgM genes
| العنوان: | Allelic exclusion in transgenic mice carrying mutant human IgM genes |
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| المؤلفون: | Albert C. Shaw, Juanita Campos-Torres, Philip Leder, Eric Sinn, Michel C. Nussenzweig |
| المصدر: | The Journal of Experimental Medicine |
| بيانات النشر: | The Rockefeller University Press, 1988. |
| سنة النشر: | 1988 |
| مصطلحات موضوعية: | Genetically modified mouse, Regulation of gene expression, Genes, Immunoglobulin, Immunoglobulin mu-Chains, Transgene, Immunology, Mutant, Receptors, Antigen, B-Cell, Mice, Transgenic, Articles, Biology, Molecular biology, Allelic exclusion, Mice, Gene Expression Regulation, Gene expression, Immunology and Allergy, Immunoglobulin heavy chain, Animals, Humans, RNA, Messenger, Gene, Alleles |
| الوصف: | Expression of the membrane-bound version of the human mu chain in transgenic mice results in the allelic exclusion of endogenous mouse Ig heavy chain genes (6). The secreted version of the human Ig transgene has no such effect. F1 hybrid animals that carry transgenes for both secreted and membrane-bound human mu chains produce both forms of the human heavy chain while strongly suppressing endogenous mouse mu expression. The simultaneous expression of the two rearranged transgenes in primary B cells suggests that allelic exclusion operates before the formation of a second functionally rearranged heavy chain gene in vivo. |
| اللغة: | English |
| تدمد: | 1540-9538 0022-1007 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4509ac0365b058141d71d538ad614305 http://europepmc.org/articles/PMC2189689 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4509ac0365b058141d71d538ad614305 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
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