Pregnancy imparts distinct systemic adaptive immune function
| العنوان: | Pregnancy imparts distinct systemic adaptive immune function |
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| المؤلفون: | Catherine Demery‐Poulos, Roberto Romero, Yi Xu, Marcia Arenas‐Hernandez, Derek Miller, Li Tao, Jose Galaz, Marcelo Farias‐Jofre, Gaurav Bhatti, Valeria Garcia‐Flores, Megan Seyerle, Adi L. Tarca, Nardhy Gomez‐Lopez |
| المصدر: | American Journal of Reproductive Immunology. 88 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | B-Lymphocytes, Reproductive Medicine, Pregnancy, Immunology, Leukocytes, Mononuclear, Humans, Obstetrics and Gynecology, Immunology and Allergy, Female, CD8-Positive T-Lymphocytes, Lymphocyte Activation, Flow Cytometry |
| الوصف: | Pregnancy represents a state of systemic immune activation that is primarily driven by alterations in circulating innate immune cells. Recent studies have suggested that cellular adaptive immune components, T cells and B cells, also undergo changes throughout gestation. However, the phenotypes and functions of such adaptive immune cells are poorly understood. Herein, we utilized high-dimensional flow cytometry and functional assays to characterize T-cell and B-cell responses in pregnant and non-pregnant women.Peripheral blood mononuclear cells from pregnant (n = 20) and non-pregnant (n = 25) women were used for phenotyping of T-cell and B-cell subsets. T-cell proliferation and B-cell activation were assessed by flow cytometry after in vitro stimulation, and lymphocyte cytotoxicity was evaluated by using a cell-based assay. Statistical comparisons were performed with linear mixed-effects models.Pregnancy was associated with modestly enhanced basal activation of peripheral CD4Maternal circulating T cells and B cells display distinct responses during pregnancy. The former may reflect the unique capacity of T cells to respond to potential threats without undergoing aberrant activation, thereby preventing systemic inflammatory responses that can lead to adverse perinatal consequences. |
| تدمد: | 1600-0897 1046-7408 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452025897c824c67a8ae1024e4492864 https://doi.org/10.1111/aji.13606 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....452025897c824c67a8ae1024e4492864 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000897 10467408 |
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