A combination of methylation and protein markers is capable of detecting gastric cancer detection by combined markers
| العنوان: | A combination of methylation and protein markers is capable of detecting gastric cancer detection by combined markers |
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| المؤلفون: | Jianhui Guo, Wenchuan Zhu, Tongmin Wang, Xiaochun Yang, Jianbiao Xu, Jianlin Song, Liangyu Zuo, Jinzhi Wu |
| المصدر: | Epigenomics. 13:1557-1570 |
| بيانات النشر: | Future Medicine Ltd, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, medicine.medical_specialty, Colorectal cancer, Atrophic gastritis, Kaplan-Meier Estimate, Disease, Cancer detection, Biology, Sensitivity and Specificity, Gastroenterology, Stomach Neoplasms, Internal medicine, Biomarkers, Tumor, Genetics, medicine, Humans, Genetic Testing, Prospective cohort study, Early Detection of Cancer, Aged, Neoplasm Staging, Aged, 80 and over, Oncogene Proteins, Disease Management, Cancer, Methylation, DNA Methylation, Middle Aged, Prognosis, medicine.disease, Protein markers, Area Under Curve, Female, Disease Susceptibility, Neoplasm Grading |
| الوصف: | Aim: This study aimed to validate a combination of mSEPT9, mRNF180 and CA724 for gastric cancer (GC) detection. Patients & methods: The performance of mSEPT9, mRNF180 and CA724 was examined in a prospective cohort study with 518 participants (151 with GC, 56 with atrophic gastritis, 87 with other gastrointestinal diseases and 224 with no evidence of disease). Results: mSEPT9, mRNF180 or CA724 alone detected 48.3, 37.1 and 43.1% of GC, respectively. The combination of mSEPT9 and mRNF180 detected 60.3% of GC, and the combination of all three markers detected 68.6% of GC. The detection sensitivity of mSEPT9 and mRNF180 was significantly higher for gastric body and in elder subjects. mSEPT9 was correlated with poorer GC survival. Conclusion: The combination of mSEPT9, mRNF180 and CA724 was adequately sensitive for GC detection. The blood mSEPT9 was predictive for GC prognosis. |
| تدمد: | 1750-192X 1750-1911 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45260af94721a662cc840deba8c07b64 https://doi.org/10.2217/epi-2021-0080 |
| رقم الأكسشن: | edsair.doi.dedup.....45260af94721a662cc840deba8c07b64 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 1750192X 17501911 |
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