Characterization of the equine infectious anaemia virus S2 protein
| العنوان: | Characterization of the equine infectious anaemia virus S2 protein |
|---|---|
| المؤلفون: | Alan J. Kingsman, Soonsang Yoon, Kyriacos A. Mitrophanous, Stuart A. Wilson, Susan M. Kingsman |
| المصدر: | Journal of General Virology. 81:2189-2194 |
| بيانات النشر: | Microbiology Society, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | COS cells, Base Sequence, viruses, Molecular Sequence Data, Group-specific antigen, Biology, Virology, Virus, Cell Line, Viral Proteins, Cytoplasm, Cell culture, COS Cells, Viral structural protein, Animals, Humans, Electrophoresis, Polyacrylamide Gel, Amino Acid Sequence, Peptide sequence, Function (biology) |
| الوصف: | S2 is an accessory protein of equine infectious anaemia virus (EIAV), the function of which is unknown. In order to gain insight into the function of S2, the intracellular localization of the protein, its interaction with viral proteins and its incorporation into viral particles have been investigated. Immunolocalization of S2 revealed punctate staining in the cytoplasm and the S2 protein co-precipitated with the EIAV Gag precursor. Despite overexpression of S2 through the use of a codon-optimized sequence, there was no preferential association of S2 with EIAV particles. These data suggest that S2 may function to organize the Gag protein during particle assembly in the cytoplasm but that it is unlikely to be involved in the early stages of the virus life-cycle. |
| تدمد: | 1465-2099 0022-1317 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4536bc7edb41b6f2910dbbdee1635028 https://doi.org/10.1099/0022-1317-81-9-2189 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4536bc7edb41b6f2910dbbdee1635028 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14652099 00221317 |
|---|