Impact of change in iron status over time on clinical outcomes in heart failure according to ejection fraction phenotype
| العنوان: | Impact of change in iron status over time on clinical outcomes in heart failure according to ejection fraction phenotype |
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| المؤلفون: | Gerry Devlin, Kui Toh Gerard Leong, Robert N. Doughty, Sarah Fitzsimons, Hean Yee Ong, David Sim, A. Mark Richards, Katrina Poppe, Poh Shuan Daniel Yeo, Fazlur Jaufeerally, M. Lund, Carolyn S.P. Lam, Richard W. Troughton, Tee Joo Yeo, Lieng H. Ling, Tze P. Ng |
| المصدر: | ESC Heart Failure ESC Heart Failure, Vol 8, Iss 6, Pp 4572-4583 (2021) |
| بيانات النشر: | John Wiley and Sons Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Iron, Cohort Studies, Risk Factors, Internal medicine, medicine, Diseases of the circulatory (Cardiovascular) system, Humans, Prospective Studies, Mortality, Heart Failure, Ejection fraction, Proportional hazards model, business.industry, Iron deficiency, Hazard ratio, Stroke Volume, Original Articles, medicine.disease, Confidence interval, Heart failure with preserved ejection fraction, Phenotype, RC666-701, Heart failure, Cohort, Cardiology, Original Article, Female, Cardiology and Cardiovascular Medicine, business, Rehospitalization, Cohort study |
| الوصف: | Aims The importance of iron deficiency (ID) in heart failure with preserved ejection fraction (HFpEF) is unknown. In HF with reduced ejection fraction (HFrEF), ID is reported as an independent predictor of mortality in HF although not all published studies agree. Different definitions of ID have been assessed, and the natural history of untreated ID not established, which may explain the conflicting results. This study aimed to assess the relationship between ID and mortality in HFpEF, clarify which definition of ID correlates best with outcomes in HFrEF, and determine the prognostic importance of change in ID status over time. Methods and results Analyses were conducted on data from 1563 patients participating in a prospective international cohort study comparing HFpEF with HFrEF. Plasma samples from baseline and 6 month visits were analysed for the presence of ID. Two ID definitions were evaluated: IDFerritin = ‘ferritin |
| اللغة: | English |
| تدمد: | 2055-5822 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4549291da60dbed6d04bcffef3cd6e6e http://europepmc.org/articles/PMC8712912 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4549291da60dbed6d04bcffef3cd6e6e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20555822 |
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