Antibiotic-Resistant Septicemia in Pediatric Oncology Patients Associated with Post-Therapeutic Neutropenic Fever
| العنوان: | Antibiotic-Resistant Septicemia in Pediatric Oncology Patients Associated with Post-Therapeutic Neutropenic Fever |
|---|---|
| المؤلفون: | José Erik Urrutia Favila, Adan Peña Barreto, Ivanka Alejandra Aguilar Velazco, Andrea Ibarra Moreno, Tomás Barrientos Fortes, José Marcos Félix Castro, Sandra Georgina Solano-Gálvez, Juan Antonio González-Barrios, Guadalupe Lizeth Ortega Ortuño, Jorge Andrés Abello Vaamonde, Rosalino Vázquez-López, Omar Rivero Rojas |
| المصدر: | Antibiotics Antibiotics, Vol 8, Iss 3, p 106 (2019) |
| بيانات النشر: | MDPI, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Microbiology (medical), medicine.medical_specialty, medicine.medical_treatment, Review, Biochemistry, Microbiology, pandrug-resistant (PDR) bacteria, Sepsis, 03 medical and health sciences, 0302 clinical medicine, Antibiotic resistance, extensively drug-resistant (XDR) bacteria, multidrug-resistant (MDR) bacteria, medicine, childhood cancer, Pharmacology (medical), 030212 general & internal medicine, General Pharmacology, Toxicology and Pharmaceutics, Intensive care medicine, Mexico, post-therapeutic neutropenic fever, business.industry, Septic shock, Incidence (epidemiology), Mortality rate, Risk of infection, lcsh:RM1-950, septicemia, Cancer, medicine.disease, Radiation therapy, Infectious Diseases, lcsh:Therapeutics. Pharmacology, 030220 oncology & carcinogenesis, business |
| الوصف: | Death in cancer patients can be caused by the progression of tumors, their malignity, or other associated conditions such as sepsis, which is a multiphasic host response to a pathogen that can be significantly amplified by endogenous factors. Its incidence is continuously rising, which reflects the increasing number of sick patients at a higher risk of infection, especially those that are elderly, pediatric, or immunosuppressed. Sepsis appears to be directly associated with oncological treatment and fatal septic shock. Patients with a cancer diagnosis face a much higher risk of infections after being immunosuppressed by chemotherapy, radiotherapy, or anti-inflammatory therapy, especially caused by non-pathogenic, Gram-negative, and multidrug-resistant pathogens. There is a notorious difference between the incidence and mortality rates related to sepsis in pediatric oncologic patients between developed and developing countries: they are much higher in developing countries, where investment for diagnosis and treatment resources, infrastructure, medical specialists, cancer-related control programs, and post-therapeutic care is insufficient. This situation not only limits but also reduces the life expectancy of treated pediatric oncologic patients, and demands higher costs from the healthcare systems. Therefore, efforts must aim to limit the progression of sepsis conditions, applying the most recommended therapeutic regimens as soon as the initial risk factors are clinically evident—or even before they are, as when taking advantage of machine learning prediction systems to analyze data. |
| اللغة: | English |
| تدمد: | 2079-6382 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455fd6d53bbc8ce1cf3e7cda2b0fe200 http://europepmc.org/articles/PMC6783913 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....455fd6d53bbc8ce1cf3e7cda2b0fe200 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20796382 |
|---|