Ezetimibe attenuates experimental diabetes and renal pathologies via targeting the advanced glycation, oxidative stress and AGE-RAGE signalling in rats
| العنوان: | Ezetimibe attenuates experimental diabetes and renal pathologies via targeting the advanced glycation, oxidative stress and AGE-RAGE signalling in rats |
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| المؤلفون: | M. Salman Khan, Abdulrahman A. Alatar, Mohammad Faisal, Rabia Nabi, Chandra Prakash Chaturvedi, Saheem Ahmad, Arunim Shah, Sahir Sultan Alvi |
| المصدر: | Archives of Physiology and Biochemistry. :1-16 |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Physiology, medicine.medical_treatment, 030209 endocrinology & metabolism, medicine.disease_cause, RAGE (receptor), Diabetic nephropathy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Glycation, Physiology (medical), Diabetes mellitus, Internal medicine, Medicine, Creatinine, business.industry, Insulin, General Medicine, medicine.disease, Endocrinology, chemistry, 030220 oncology & carcinogenesis, business, Oxidative stress, Lipoprotein |
| الوصف: | The current in-vivo study was premeditated to uncover the protective role of ezetimibe (EZ) against advanced glycation endproducts (AGEs)-related pathologies in experimental diabetes. Our results showed that EZ markedly improved the altered biochemical markers of diabetes mellitus (DM) (FBG, HbA1c, insulin, microalbumin, and creatinine) and cardiovascular disease (in-vivo lipid/lipoprotein level and hepatic HMG-CoA reductase activity) along with diminished plasma carboxymethyl-lysine (CML) and renal fluorescent AGEs level. Gene expression study revealed that EZ significantly down-regulated the renal AGEs-receptor (RAGE), nuclear factor-κB (NFκB-2), transforming growth factor-β (TGF-β1), and matrix metalloproteinase-2 (MMP-2) mRNA expression, however, the neuropilin-1 (NRP-1) mRNA expression was up-regulated. In addition, EZ also maintained the redox status via decreasing the lipid peroxidation and protein-bound carbonyl content (CC) and increasing the activity of high-density lipoprotein (HDL)-associated-paraoxonase-1 (PON-1) and renal antioxidant enzymes as well as also protected renal histopathological features. We conclude that EZ exhibits antidiabetic and reno-protective properties in diabetic rats. |
| تدمد: | 1744-4160 1381-3455 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459b7ef556825651314fb2015abde67b https://doi.org/10.1080/13813455.2021.1874996 |
| رقم الأكسشن: | edsair.doi.dedup.....459b7ef556825651314fb2015abde67b |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17444160 13813455 |
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